Article

Tolerance to the anticonvulsant effect of morphine in mice: blockage by ultra-low dose naltrexone.

Department of Pharmacology, School of Pharmacy, Medical Sciences/University of Tehran, Tehran, Iran.
Epilepsy research (impact factor: 2.48). 01/2009; 83(2-3):261-4. DOI:10.1016/j.eplepsyres.2008.10.011
Source: PubMed

ABSTRACT The present study evaluated the development of tolerance to the anticonvulsant effect of morphine in a mouse model of clonic seizures induced by pentylenetetrazole, and whether ultra-low doses of the opioid receptor antagonist naltrexone which selectively block G(s) opioid receptors were capable of preventing the observed tolerance. The results showed that the morphine anticonvulsant effect could be subject to tolerance after repeated administration. Both the development and expression of tolerance were inhibited by ultra-low doses of naltrexone, suggesting the possible involvement of G(s)-coupled opioid receptors in the development of tolerance to the anticonvulsant effect of morphine.

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Keywords

anticonvulsant effect
 
clonic seizures induced
 
G(s)-coupled opioid receptors
 
morphine anticonvulsant effect
 
mouse model
 
observed tolerance
 
opioid receptor antagonist naltrexone
 
possible involvement
 
selectively block G(s)
 
tolerance
 
ultra-low doses
 

Mehdi Ghasemi