Cervical cancer survivorship in a population based sample
Center of Community Alliance for Research and Education, Division of Population Sciences, City of Hope National Medical Center, 1500 E. Duarte Rd, Duarte, CA 91010, USA. Gynecologic Oncology
(Impact Factor: 3.77).
02/2009; 112(2):358-64. DOI: 10.1016/j.ygyno.2008.11.002
Though cervical cancer is preventable, this cancer nonetheless poses serious mortality and morbidity threats to American women and women globally. The purpose of this study is to utilize a multidimensional framework to assess Health-related Quality of Life (HRQOL) and its salient predictors among a population based sample of cervical cancer survivors.
A cross-sectional design was used with a population-based sample ascertained from the California Cancer Surveillance Program. Descriptive, bivariate and multivariate regression analyses were conducted.
Participants were 560 cervical cancer survivors: English-speaking Latina- (n=88), Spanish-speaking Latina- (n=199) and European- (n=273) Americans. The greatest concerns were documented for family/social and emotional well-being, and body image and sexual health. In general, Latina-Americans reported poorer overall HRQOL, functional, emotional, and social/family wellbeing compared to European-Americans. Differences in HRQOL persisted by ethnic/language group after controlling for covariates. Radiation, comorbidity, role limitations, perceived health status, psychological wellbeing, body image, sexual impact, doctor-patient relationship, and social support were significant predictors of overall HRQOL. The regression model explained 58% of the variance in predicting HRQOL.
These cervical cancer survivors reported poor to moderate HRQOL with persistent psychosocial challenges. Our findings indicate that lower SES, monolingual Latinas are at greatest risk for poor HRQOL outcomes. Clinicians should pay attention to their patients' socio-ecological context as a risk factor for poorer outcomes; and provide early referrals to resources that are low cost and culturally and linguistically appropriate.
Available from: Julia Tang
- "These findings may be related to a common factor " wealth " . Cervical cancer is primarily a cancer of the poor and underserved . This is reflected in the fact that the greater sampling of Latina women resulted in the lower variability in reported income and led to a sample where only 18% were at a moderate income level by cost of living standards in LA County. "
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ABSTRACT: This study investigates the association between health-related quality of life (HRQOL) outcomes and survival status among a population-based cohort diagnosed with invasive cancer of the cervix uteri.
This study is based on data from 353 multiethnic cervical cancer survivors (CCS) recruited through the California Cancer Surveillance Program. The independent variable is HRQOL measured by the FACT-CX (FACT-G plus additional items) and the SF-12. The dependent variable is survival from date of the HRQOL survey. Kaplan-Meier estimates and univariate and multivariate Cox Proportional Hazards Regression models were used to examine the relationship between HRQOL and survival.
In the Kaplan-Meier analyses, the FACT-CX functional well-being score equal to or above the median score was significantly associated with improved overall survival (X(2)=7.19; p=0.007). Significant differences in survival were observed for the SF-12 physical and mental health component scores. In the multivariate Cox regression analyses, the final model indicated that the FACT-CX total scores, functional well-being, and additional cervical cancer concerns subscales, and the SF-12 physical and mental component summary scores significantly influenced survival, after controlling for medical characteristics. However, the FACT components that do not include cervical cancer specific items including mean standardized FACT-G and physical, emotional, and social/family well-being subscales were not predictors of survival before and after adjustment for covariates.
The results of this study advance the current scientific knowledge by confirming that HRQOL outcomes, in particular the physical, function and mental health dimensions are associated with survival for CCS. These findings highlight the utility of cancer site specific HRQOL data to inform the psychosocial and symptom management aspects, as well as the medical follow-up care practice and research that may extend life.
Gynecologic Oncology 04/2010; 118(1):35-42. DOI:10.1016/j.ygyno.2010.02.027 · 3.77 Impact Factor
Available from: Alice Yuen Loke
- "The cancer site-specific QOL instruments were developed to measure the QOL of cervical cancer patients. This category consisted of 3 scales: the EORTC Quality of Life Questionnaire-Cervix-24items (QLQ-Cx24) , the Functional Assessment of Cancer Therapy-Cervix (FACT-Cx) [34,35], and the Quality of Life Instruments for Cancer Patients-Cervical Cancer (QLICP-CE) . The survivor-specific category included the Cancer Survivors' Unmet Needs (CaSUN) scale , which was developed to assess QOL among long-term cancer survivors using a needs-based approach. "
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ABSTRACT: Women with cervical cancer now have relatively good 5-year survival rates. Better survival rates have driven the paradigm in cancer care from a medical illness model to a wellness model, which is concerned with the quality of women's lives as well as the length of survival. Thus, the assessment of quality of life among cervical cancer survivors is increasingly paramount for healthcare professionals. The purposes of this review were to describe existing validated quality of life instruments used in cervical cancer survivors, and to reveal the implications of quality of life measurement for Chinese cervical cancer survivors.
A literature search of five electronic databases was conducted using the terms cervical/cervix cancer, quality of life, survivors, survivorship, measurement, and instruments. Articles published in either English or Chinese from January 2000 to June 2009 were searched. Only those adopting an established quality of life instrument for use in cervical cancer survivors were included.
A total of 11 validated multidimensional quality of life instruments were identified from 41 articles. These instruments could be classified into four categories: generic, cancer-specific, cancer site-specific and cancer survivor-specific instruments. With internal consistency varying from 0.68-0.99, the test-retest reliability ranged from 0.60-0.95 based on the test of the Pearson coefficient. One or more types of validity supported the construct validity. Although all these instruments met the minimum requirements of reliability and validity, the original versions of these instruments were mainly in English.
Selection of an instrument should consider the purpose of investigation, take its psychometric properties into account, and consider the instrument's origin and comprehensiveness. As quality of life can be affected by culture, studies assessing the quality of life of cervical cancer survivors in China or other non-English speaking countries should choose or develop instruments relevant to their own cultural context. There is a need to develop a comprehensive quality of life instrument for Chinese cervical cancer survivors across the whole survivorship, including immediately after diagnosis and for short- (less than 5 years) and long-term (more than 5 years) survivorship.
Health and Quality of Life Outcomes 03/2010; 8(1):30. DOI:10.1186/1477-7525-8-30 · 2.12 Impact Factor
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ABSTRACT: Although hydrogenated amorphous silicon (a-Si:H) is inherently disadvantaged in terms of speed and stability compared to polycrystalline or crystalline Si, there is an overwhelming need for this mature technology in several newly emerging and significant application areas. Here, the question arises as to whether circuit techniques can be employed to compensate for its intrinsic material shortcomings so as to meet performance requirements. The paper reviews precisely these challenges. Specifically, it addresses the development of compact thin film transistor (TFT) circuit models and examines design considerations pertinent to thin film circuits, such as on-pixel current drivers and amplifiers, whose integration requires nonconventional design solutions to deal with the high material resistivity and high instability. The family of circuits presented here are critical to two application areas: the active matrix organic light emitting diode (AMOLED) display and digital fluoroscopy for medical applications.
Microelectronics, 2002. MIEL 2002. 23rd International Conference on; 02/2002
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