Preparing of pellets by extrusion/spheronization using different types of equipment and process conditions

Department of Pharmaceutical Technology, University of Szeged , Szeged , Hungary and.
Drug Development and Industrial Pharmacy (Impact Factor: 2.1). 04/2013; 40(6). DOI: 10.3109/03639045.2013.783588
Source: PubMed


The focus of this work was to produce matrix pellets made by extrusion/ spheronization using two types of equipment. The aim was to accomplish the laboratory-scale I process that has been already optimized and accepted with another type of equipment (laboratory-scale II).

A matrix pellet formulation consisting of MCC, Eudragit NE 30D and diclofenac sodium was used in the two types of equipment. Physico-chemical parameters and the dissolution profiles of the pellets in phosphate buffer pH 6.8 were compared.

Pellets from both processes were similar in shape and tensile strength. They differed in particle size and dissolution profile. This may be contributed to different spheronization conditions.

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