Article

Aiming at Neuroblastoma and Hitting Other Worthy Targets

1 Departments of Pediatrics, Neurology, and Neurobiology & Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Journal of child neurology (Impact Factor: 1.59). 04/2013; 28(6). DOI: 10.1177/0883073813483173
Source: PubMed

ABSTRACT Neuroblastoma is, at once, the most common and deadly extracranial solid tumor of childhood. Efforts aimed at targeting the neural characteristics of these tumors have taught us much about neural crest cell biology, apoptosis induction in the nervous system, and neurotrophin receptor signaling and intracellular processing. But neuroblastoma remains a formidable enemy to the oncologist and an enigmatic target to the neuroscientist.

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