Article

Dose-response associations between number and frequency of substance use and high-risk sexual behaviors among HIV-negative substance-using men who have sex with men (SUMSM) in San Francisco.

aSan Francisco Department of Public Health, San Francisco, CA bUniversity of California San Francisco, San Francisco, CA cDivision of HIV/AIDS Prevention, NCHHSTP, CDC, Atlanta, GA.
JAIDS Journal of Acquired Immune Deficiency Syndromes (Impact Factor: 4.39). 04/2013; DOI: 10.1097/QAI.0b013e318293f10b
Source: PubMed

ABSTRACT We evaluated the relationship between frequency and number of substances used and HIV risk (i.e. serodiscordant unprotected anal intercourse[SDUAI]) among 3173 HIV-negative substance-using MSM. Compared to non-users, the adjusted odds ratio(AOR) for SDUAI among episodic and at least weekly users, respectively, was 3.31(95%CI 2.55-4.28) and 5.46(3.80-7.84) for methamphetamine, 1.86(1.51-2.29) and 3.13(2.12-4.63) for cocaine, and 2.08(1.68-2.56) and 2.54(1.85-3.48) for poppers. Heavy alcohol drinkers reported more SDUAI than moderate drinkers (AOR=1.90(1.43-2.51)). Compared to non-users, AORs for using one, two, and ≥ three substances were 16.81(12.25-23.08), 27.31(18.93-39.39), and 46.38(30.65-70.19), respectively. High-risk sexual behaviors were strongly associated with frequency and number of substances used.

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