Article

Polarizing pathways: Balancing endothelial polarity, permeability, and lumen formation.

Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 USA.
Experimental Cell Research (Impact Factor: 3.37). 04/2013; DOI: 10.1016/j.yexcr.2013.03.028
Source: PubMed

ABSTRACT •Key molecules known to regulate endothelial permeability also control polarity.•Complexes required for apical–basal polarity remain critical for lumen formation.•Angiogenesis and barrier integrity play opposing roles with similar mediators.

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