Article

Magnetoencephalography reveals altered auditory information processing in youth with obsessive-compulsive disorder

Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: .
Psychiatry Research (Impact Factor: 2.68). 03/2013; DOI: 10.1016/j.pscychresns.2012.11.011
Source: PubMed

ABSTRACT Patients with obsessive-compulsive disorder (OCD) often report sensory intolerances which may lead to significant functional impairment. This study used auditory evoked fields (AEFs) to address the question of whether neural correlates of sensory auditory information processing differ in youth with OCD compared with healthy comparison subjects (HCS). AEFs, recorded with a whole head 275-channel magnetoencephalography system, were elicited in response to binaural auditory stimuli from 10 pediatric subjects with OCD (ages 8-13, mean 11 years, 6 males) and 10 age- and gender-matched HCS. Three major neuromagnetic responses were studied: M70 (60-80ms), M100 (90-120ms), and M150 (130-190ms). When compared with HCS, subjects with OCD demonstrated delayed latency of the M100 response. In subjects with OCD the amplitude of the M100 and M150 responses was significantly greater in the right hemisphere compared with the left hemisphere. Current results suggest that when compared with HCS, subjects with OCD have altered auditory information processing, evident from the delayed latency of the M100 response, which is thought to be associated with the encoding of physical stimulus characteristics. Interhemispheric asymmetry with increased M100 and M150 amplitudes over the right hemisphere compared with the left hemisphere was found in young OCD subjects. These results should be interpreted with caution due to the high variability rate of responses in both HCS and OCD subjects, as well as the possible effect of medication in OCD subjects.

0 Followers
 · 
85 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The present study explored the prevalence and descriptive characteristics of hyperacusis, defined as unusual intolerance of ordinary environmental sounds. Two ways of collecting data were used in the study: the first was a postal survey of a random sample, to which 589 responded (59.7% response rate); the second was the internet, and 595 self-recruited individuals responded to a call for participants via a banner on a web page (51.9% response rate). The point prevalence rates of hyperacusis were 9% in the internet group and 8% in the postal group. Exclusion of participants who reported hearing impairment resulted in point prevalence rates of 7.7% (n = 39) and 5.9% (n = 28) respectively. The data collection format did not result in any substantial differences. Hyperacusis was associated with concentration difficulties, use of ear protection, avoidance, tension, and sensitivity to light/colours. The present data suggest that hyperacusis is a common problem.
    International Journal of Audiology 01/2003; 41(8):545-54. · 1.43 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Auditory environments vary as a result of the appearance and disappearance of acoustic sources, as well as fluctuations characteristic of the sources themselves. The appearance of an object is often manifest as a transition in the pattern of ongoing fluctuation, rather than an onset or offset of acoustic power. How does the system detect and process such transitions? Based on magnetoencephalography data, we show that the temporal dynamics and response morphology of the neural temporal-edge detection processes depend in precise ways on the nature of the change. We measure auditory cortical responses to transitions between "disorder," modeled as a sequence of random frequency tone pips, and "order," modeled as a constant tone. Such transitions embody key characteristics of natural auditory edges. Early cortical responses (from approximately 50 ms post-transition) reveal that order-disorder transitions, and vice versa, are processed by different neural mechanisms. Their dynamics suggest that the auditory cortex optimally adjusts to stimulus statistics, even when this is not required for overt behavior. Furthermore, this response profile bears a striking similarity to that measured from another order-disorder transition, between interaurally correlated and uncorrelated noise, a radically different stimulus. This parallelism suggests the existence of a general mechanism that operates early in the processing stream on the abstract statistics of the auditory input, and is putatively related to the processes of constructing a new representation or detecting a deviation from a previously acquired model of the auditory scene. Together, the data reveal information about the mechanisms with which the brain samples, represents, and detects changes in the environment.
    The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 06/2007; 27(19):5207-14. DOI:10.1523/JNEUROSCI.0318-07.2007 · 6.75 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: We use magnetoencephalography to study human auditory cortical processing of changes in interaural correlation (IAC). We studied transitions from correlated (identical signals at the 2 ears) to uncorrelated (different signals at the 2 ears) or vice versa for two types of wide-band noise stimuli: CHANGE signals contained a single IAC change (or none) and ALT signals alternated between correlated and uncorrelated at a constant rate. The relevant transitions, from correlated to uncorrelated or vice versa, are physically identical in both stimulus conditions, but auditory cortical response patterns differed substantially. CHANGE stimuli exhibited a response asymmetry in their temporal dynamics and magnetic field morphology according to the direction of change. Distinct field patterns indicate the involvement of separate neural substrates for processing, and distinct latencies are suggestive of different temporal integration windows. In contrast, the temporal dynamics of responses to change in the ALT stimuli did not differ substantially according to the direction of change. Notably, the uncorrelated-to-correlated transition in the ALT stimuli showed a first deflection approximately 90 ms earlier than for the same transition in the CHANGE stimuli and with an opposite magnetic field distribution. This finding suggests that as early as 50 ms after the onset of an IAC transition, a given physical change is processed differentially depending on stimulus context. Consequently, even early cortical activation cannot be interpreted independently of the specific long-term stimulus context used in the experiment.
    Journal of Neurophysiology 08/2007; 98(1):224-31. DOI:10.1152/jn.00359.2007 · 3.04 Impact Factor