Reactive lymphadenopathies that mimic lymphoma: Entities of unknown etiology

Division of Hematopathology, University of Texas/M.D. Anderson Cancer Center, Houston, Texas. Electronic address: .
Seminars in Diagnostic Pathology (Impact Factor: 2.56). 03/2013; 30(2). DOI: 10.1053/j.semdp.2012.08.007
Source: PubMed

ABSTRACT Kikuchi-Fujimoto disease, Kimura disease, Rosai-Dorfman disease and IgG4 related lymphadenopathy may present with enlarging masses clinically mimicking lymphoma. A combination of clinical and histologic findings is necessary to diagnose these important rare entities, which may occasionally have aggressive clinical behavior. The recognition of these disorders is important in order to avoid misdiagnosis of malignancy, other systemic diseases such as systemic lupus, and to institute correct management and therapy, such as steroid treatment for IgG4 related lymphadenopathy. The underlying etiologies of these diseases are not completely clear at present, however, their recognition has become more common as diagnostic techniques improve. Their diagnosis and recognition may help to elucidate their underlying pathobiology.

Download full-text


Available from: Dennis P O'Malley, Sep 28, 2015
74 Reads
  • Source
    The Journal of pediatrics 01/2014; 164(4). DOI:10.1016/j.jpeds.2013.12.001 · 3.79 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Rosai-Dorfman disease (RDD) is a benign histiocytic proliferative disorder characterized by the accumulation of histiocytes in lymph nodes and various other organs. RDD seldom involves the central nervous system, and cases of purely intracranial RDD are particularly rare. We report a case of purely intracranial RDD involving the brainstem that was diagnosed at autopsy. A 68-year-old woman visited our hospital because of visual disturbances and loss of energy. Magnetic resonance imaging revealed an obscure mass in the brainstem. Despite exhaustive work-ups, the etiology of the intracranial mass remained unclear. The patient died of respiratory depression, and an autopsy was performed for pathological investigation. Macroscopically, a pink pale mass 2.5 cm in diameter was found in the brainstem, with no attachment to the dura. Histologically, it was composed of histiocytic cells with incorporation of small lymphocytes (emperipolesis). Immunohistochemical staining revealed that the cells were positive for CD68 and S100 and negative for CD1a, consistent with a diagnosis of RDD. Purely intracranial RDD is extremely rare and considered benign. To date, nine cases (including ours) have been reported. To our knowledge, this is the first case of intracranial RDD with autopsy. Although generally considered benign, RDD involving the brainstem might be lethal. © 2015 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd.
    Pathology International 07/2015; DOI:10.1111/pin.12331 · 1.69 Impact Factor