ATRP in the design of functional materials for biomedical applications. Prog Polym Sci

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, 2 USA.
Progress in Polymer Science (Impact Factor: 26.93). 01/2012; 37(1):18-37. DOI: 10.1016/j.progpolymsci.2011.08.001
Source: PubMed


Atom Transfer Radical Polymerization (ATRP) is an effective technique for the design and preparation of multifunctional, nanostructured materials for a variety of applications in biology and medicine. ATRP enables precise control over macromolecular structure, order, and functionality, which are important considerations for emerging biomedical designs. This article reviews recent advances in the preparation of polymer-based nanomaterials using ATRP, including polymer bioconjugates, block copolymer-based drug delivery systems, cross-linked microgels/nanogels, diagnostic and imaging platforms, tissue engineering hydrogels, and degradable polymers. It is envisioned that precise engineering at the molecular level will translate to tailored macroscopic physical properties, thus enabling control of the key elements for realized biomedical applications.

Download full-text


Available from: Jung Kwon Oh, May 06, 2014
37 Reads
    • "There are several reports on the synthesis of copolymers and the study of their properties, as these copolymers are important materials in the several fields of natural science, for example, colloid science and biochemistry, as well as in industrial fields [11] [12]. Moreover, the interface of ATRP with biology has always been one of the most attractive areas for applications due to ATRP's robust nature and ability to grow polymers from a variety of surfaces [10]. The essential feature of original " normal " (NI) ATRP is controlled by an equilibrium between a low concentration of active propagating species and a larger number of dormant chains, predominately in the form of initiating alkyl halides/macromolecular species (R n –X, where R n represents growing polymer chain and X is halogen atom) [13] [14] (Scheme 1). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Atom transfer radical polymerization (ATRP) is currently one of the most often used synthetic polymerization methods to prepare well-defined copolymers with complex architecture. This review covers some fundamentals of ATRP, presents new ATRP initiating processes with ppm amounts of copper catalysts and various reducing agents together with recent developed electrochemically controlled ATRP, as well as discusses ATRP enables to precise control over macromolecular structure, order, and functionality. Moreover, this review briefly describes some of the copolymer coating materials that can now be prepared e.g., protective coatings with increased hydrophobicity, functional bioactive surfaces and functional biomaterials, as well as highlights some of the commercialization efforts currently underway. The research activities in the last decade indicate that ATRP has become an essential tool for the design and synthesis of advanced, noble and novel copolymer coatings.
    Progress in Organic Coatings 05/2014; 77(5):913-948. DOI:10.1016/j.porgcoat.2014.01.027 · 2.36 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: A well-defined thermoresponsive poly(ethylene glycol)-block-poly(N-isopropylacrylamide)-block-poly(ε-caprolactone) (PEG(43)-b-PNIPAM(82)-b-PCL(87)) triblock copolymer was synthesized by combination of atom transfer radical polymerization (ATRP), ring-opening polymerization (ROP), and click chemistry. The synthesis included the four steps, and all the structures of the polymers were determined. The thermoresponsive triblock copolymer can disperse in water at room temperature to form core-shell-corona micelles with the hydrophobic PCL block as core, the thermoresponsive PNIPAM block as shell, and the hydrophilic PEG block as corona. At temperatures above the lower critical solution temperature (LCST) of the PNIPAM block, the PNIPAM chains gradually collapse on the PCL core to shrink the size and change the structure of the resultant core-shell-corona micelles with temperature increasing.
    The Journal of Physical Chemistry B 11/2011; 115(50):14947-55. DOI:10.1021/jp208494w · 3.30 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The incorporation and presentation of cell recognition ligands on the surfaces of biodegradable blood-vessel implants to promote endothelialisation is considered to be a promising approach to prevent platelet aggregation and hence thrombogenesis. In this study, cell-adhesive collagen was covalently immobilised onto polycaprolactone (PCL) substrates via surface-initiated atom transfer radical polymerization (ATRP) to improve cell-material interactions. Functional polymer brushes of poly(methacrylic acid) (P(MAA)) containing dense and reactive carboxyl groups (-COOH) were formed on the PCL substrates in a controllable manner. The amount of collagen, which was conjugated to the pendant carboxyl groups via carbodiimide chemistry, increased with the concentration of -COOH groups on the grafted P(MAA) brushes. The affinity and growth of endothelial cells (ECs) were found to be significantly improved on the collagen-immobilised PCL substrates, and this improvement is positively correlated with the amount of c
    Journal of Materials Chemistry 07/2012; 22(26-26):13039-13049. DOI:10.1039/C2JM31213A · 7.44 Impact Factor
Show more