Kawasaki disease and subsequent risk of allergic diseases: a population-based matched cohort study

BMC Pediatrics (Impact Factor: 1.92). 03/2013; 13(1):38. DOI: 10.1186/1471-2431-13-38
Source: PubMed

ABSTRACT BACKGROUND: The risk of allergic diseases among Kawasaki disease (KD) patients relative to the general population is not known. The aim of this study was to perform a population-based cohort study to investigate the risk of allergic diseases among children after KD in Taiwan- a country with the third highest incidence of KD in the world. METHODS: Data were obtained from the Taiwan National Health Insurance Research Database. In total, 253 patients who were 5 years of age or younger and had a first-time hospitalization with a diagnosis of KD between 1997 and 2005 were included as the study cohort and 1,012 non-KD patients matched for age and sex were included as comparison cohort. Multivariate Cox proportional hazard regression model was used to adjust for confounding and to compare the 6-year allergic-free survival rate between these two cohorts. RESULTS: The incidence rate of allergic diseases (184.66 per 1000 person-year) was significantly higher in the KD cohort than in the control cohort (124.99 per 1000 person-years). After adjusting for potential confounders, the adjusted hazard ratios of asthma and allergic rhinitis were 1.51 (95% confidence interval = 1.17-1.95) and 1.30 (95% confidence interval = 1.04-1.62), respectively. CONCLUSION: We conclude that KD patients were at an increased risk for allergic diseases compared with the comparison cohort.


Available from: WC Chang, May 19, 2015
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    ABSTRACT: Purpose Growing evidence reveals a link Kawasaki disease (KD) and allergic diseases. This population-based case control study is to investigate the onset of allergic diseases in children and the associated risks of KD. Methods From 1996 to 2008, 2748 children with KD and 10,656 randomly selected controls were enrolled. Odds ratios (OR) of KD were calculated for the association with pre-existing allergic diseases. Results The children with a single allergic disease had an increased risk of KD, with adjusted odds ratios of having KD of 1.82 for urticaria (95% confidence interval [CI], 1.54-2.14), 1.44 for allergic rhinitis (95% CI, 1.23-1.70), and 1.22 for atopic dermatitis (95% CI, 1.06-1.39).The adjusted odds ratios increased with the number of concurrent allergic diseases, from 1.61 (95% CI, 1.43-1.82) for those with only one allergic disease to 1.71 (95% CI, 1.48-1.98) for those with at least two allergic diseases. The children who made two or more medical visits for associated allergic diseases per year had an increased risk of KD. Conclusions Children with onset of allergic diseases were at increased risk for KD, and the increased risk was associated with the cumulative effect of concurrent allergic diseases and frequency of seeking medical care.
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    03/2015; 67(3). DOI:10.1002/art.38976