Anal Human Papillomavirus Infection Among Thai Men Who Have Sex With Men With and Without HIV Infection
1The Thai Red Cross AIDS Research Centre, Bangkok, Thailand 2SEARCH, Bangkok, Thailand 3HIV-NAT, Bangkok, Thailand 4The Kirby Institute for Infections and Immunity in Society, The University of New South Wales, Sydney, NSW, Australia 5Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand 6TREAT Asia/amfAR - The Foundation for AIDS Research, Bangkok, Thailand 7Department of Medicine, University of California San Francisco, San Francisco, California, USA. JAIDS Journal of Acquired Immune Deficiency Syndromes
(Impact Factor: 4.56).
03/2013; 63(4). DOI: 10.1097/QAI.0b013e3182918a5a
HIV-positive men who have sex with men (MSM) have a higher prevalence of anal human papillomavirus (HPV) infection and anal cancer incidence than HIV-negative MSM. High-risk HPV persistence is an important risk factor for the development of anal cancer.
A total of 123 HIV-positive and 123 HIV-negative MSM were enrolled from the Thai Red Cross AIDS Research Centre in Bangkok, Thailand, and followed for 12 months. Anal sample collection for HPV genotyping was performed at every visit. HPV prevalence, incidence, clearance, and persistence were calculated. A logistic regression model was used to study factors associated with high-risk HPV persistence.
The prevalence of any anal HPV infection was 85% in HIV-positive and 58.5% in HIV-negative MSM (P < 0.0001). The prevalence of high-risk HPV infection was 57.5% in HIV-positive and 36.6% in HIV-negative MSM (P = 0.001). HPV 16 was the most common high-risk HPV type. HIV-positive MSM had a higher prevalence (22.5% vs. 9.8%, P = 0.008) and persistence (16.7% vs. 1.3%, P < 0.001) of HPV 16 than HIV-negative MSM and a trend for higher incidence (16.1 vs. 6.1 episodes/1000 person-months, incidence rate ratio 2.6, P = 0.058). HIV infection (odds ratio: 4.45, 95% confidence interval: 2.11 to 9.4, P < 0.001) and smoking in HIV-positive MSM (odds ratio: 2.3, 95% confidence interval: 1.17 to 4.5, P = 0.015) were independently associated with high-risk HPV persistence in multivariate models.
In addition to targeting HIV-positive MSM who are at higher risk for anal, high-risk HPV persistence, anal cancer prevention programs should also integrate behavioral interventions such as smoking cessation to modify risk for high-risk HPV persistence.
Available from: Gary Yu
- "* Participants that use alcohol at last penetrative sex are three times more likely to engage in receptive UAI with elective male partners (24/53, 45%) than participants that do not use alcohol (10/46, 22%). ** p-Value is calculated from the Fisher's exact test. is generally high, in this sample smoking is coupled with high rates of oral STIs, particularly high rates of oral gonorrhea (Vu, Giang, Nguyen, Clatts, & Goldsamt, 2013) as well as high rates of Human Papilloma Virus (Clatts, Giang, Goldsamt, & Yu, 2014) is of concern because, particularly when combined with smoking , high rates of HPV infection are generally associated with increased risk of oral, penile, and anal cancer (Phanuphak et al., 2013). This highlights the urgent need to develop models for effectively engaging these groups in early interventions (particularly targeted health services with which to engage and retain MSWs in HPV vaccination programs and related preventative health ser- vices). "
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ABSTRACT: HIV research in Vietnam has focused primarily on its large heroin injector population. Data on men who have sex with men [MSM], particularly the large and growing population of men who exchange sex for money or other material rewards, male sex workers [MSWs], is very limited.Methods
Data derive from a cross-sectional study of MSW, age 16-35, recruited using community sampling methods in three cities in 2010-2011, including Hanoi, Ho Chi Minh City [HCMC], and Nha Trang City (n = 710). Assessments included demographic characteristics, substance use, sexual risk, and use of health services. A series of “event” questions were used to assess the influence of alcohol and drugs on sexual risk.ResultsBoth tobacco and alcohol are initiated at a young age and most participants currently use both substances overall across all three cities. While alcohol and tobacco use precede the initiation of sex work, stimulant and opiate use are initiated following the initiation of sex work. There was substantial overlap between substance use and sexual risk, and this overlap was strongest in sexual events involving male and female elective partners rather than sex work clients.Conclusion
Although rates of HIV infection in this group are low, this may be an artifact of the young age of the sample. High rates of drug use, including alcohol, tobacco and illicit drugs, coupled with high rates of ulcerative STIs such as HPV, suggest the potential for rapid amplification of STI/HIV risk among MSW and their complex sex partnering networks.
International Journal of Drug Policy 11/2014; 26(5). DOI:10.1016/j.drugpo.2014.10.011 · 2.40 Impact Factor
Available from: Yong Poovorawan
- "Pornjarim Nilyanimit et al Asian Pacific Journal of Cancer Prevention, Vol 14, 2013 5520 (Phanuphak et al., 2013 "
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Cervical cancer is the second most common cancer in Thai women after breast cancer. Currently, the Papanicolaou (Pap) smear is the recommended procedure for cervical cancer screening in Thailand, but only a relatively small percentage of women follow this screening program. An alternative method to detect HPV genotypes associated with cervical cancer is self-sampling of urine, which is a more widely accepted method. Our study aimed to evaluate the prevalence of HPV in Thai women using urine and cervical swabs and prevalence of HPV in Thai men using urine samples.
Materials and methods:
Tumorigenic HPV detection was accomplished by electrochemical DNA chip and PCR/direct sequencing. In addition to HPV prevalence, we report the concordance between different methods and sample types. One-hundred and sixteen women and 100 men were recruited. Histological examination revealed normal cytology in 52 women, atypical squamous cells of undetermined significance (ASCUS) in 9, low-grade squamous intraepithelial lesions (LSIL) in 24, and high-grade squamous intraepithelial lesions (HSIL) in 31. One-hundred men were classified as heterosexuals (n=45) and homosexuals (n=55).
The most prevalent HPV genotype in our study was HPV16. The HPV detection rate was generally lower in urine samples compared with cervical samples. Overall, there was good agreement for the detection of carcinogenic HPV from female cervical samples between the DNA chip and PCR/ sequencing, with 88.8% total agreement and a kappa value of 0.76. In male urine samples, the level of agreement was higher in heterosexuals compared with homosexuals.
Further improvement is required to increase an overall yield of HPV DNA detection in urine samples before clinical application of a urine-based HPV screening program. The electrochemical DNA chip test is a promising technique for carcinogenic HPV detection.
Asian Pacific journal of cancer prevention: APJCP 09/2013; 14(9):5519-25. DOI:10.7314/APJCP.2013.14.9.5519 · 2.51 Impact Factor
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Carcinogenic human papillomaviruses (HPVs) cause a large proportion of anal cancers. Human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) are at increased risk of HPV infection and anal cancer compared with HIV-negative men. We evaluated risk factors for HPV infection and anal precancer in a population of HIV-infected MSM.
Our study included 305 MSM at an HIV/AIDS clinic in the Kaiser Permanente Northern California Health Maintenance Organization. Logistic regression was used to estimate associations of risk factors comparing men without anal HPV infection; men with anal HPV infection, but no precancer; and men with anal precancer.
Low CD4 count (<350 cells/mm(3)) and previous chlamydia infection were associated with an increased risk of carcinogenic HPV infection (odds ratio [OR], 3.65; 95% confidence interval [CI], 1.28-10.40 and OR, 4.24; 95% CI, 1.16-15.51, respectively). History of smoking (OR, 2.71 95% CI, 1.43-5.14), duration, recency, and dose of smoking increased the risk of anal precancer among carcinogenic HPV-positive men but had no association with HPV infection.
We found distinct risk factors for anal HPV infection and anal precancer. Risk factors for HPV infection and anal precancer are similar to established risk factors for cervical cancer progression.
The Journal of Infectious Diseases 08/2013; 208(11). DOI:10.1093/infdis/jit374 · 6.00 Impact Factor
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