Article

Neonatal Herpes Simplex Virus Infections.

Division of Pediatric Infectious Diseases, The University of Alabama at Birmingham, 1600 Seventh Avenue South, CHB 308, Birmingham, AL 35233, USA.
Pediatric Clinics of North America (Impact Factor: 2.2). 04/2013; 60(2):351-365. DOI: 10.1016/j.pcl.2012.12.005
Source: PubMed

ABSTRACT Neonatal herpes simplex virus infections are uncommon, but because of the morbidity and mortality associated with the infection they are often considered in the differential diagnosis of ill neonates. The use of polymerase chain reaction for diagnosis of central nervous system infections and the development of safe and effective antiviral therapy has revolutionized the diagnosis and management of these infants. Initiation of long-term antiviral suppressive therapy in these infants has led to significant improvement in morbidity. This article summarizes the epidemiology of neonatal herpes simplex virus infections and discusses clinical presentation, diagnosis, management, and follow up of infants with neonatal herpes disease.

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