Article

hERG channel function: beyond long QT

Department of Neuroscience, High Throughput Biology Center and Johns Hopkins Ion Channel Center (JHICC), School of Medicine, Johns Hopkins University, 733 North Broadway, Baltimore, MD 21205, USA.
Acta Pharmacologica Sinica (Impact Factor: 2.5). 03/2013; 34(3):329-35. DOI: 10.1038/aps.2013.6
Source: PubMed

ABSTRACT To date, research on the human ether-a-go-go related gene (hERG) has focused on this potassium channel's role in cardiac repolarization and Long QT Syndrome (LQTS). However, growing evidence implicates hERG in a diversity of physiologic and pathological processes. Here we discuss these other functions of hERG, particularly their impact on diseases beyond cardiac arrhythmia.

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