Correlation of ambient pollution levels and heavily-trafficked roadway proximity on the prevalence of smear-positive tuberculosis

The Johns Hopkins School of Medicine, Division of Pediatric Pulmonology, Department of Pediatrics, Children's Hospital Los Angeles, Rubenstein Child Health Building, 200 N. Wolfe Street, 3rd Floor, Baltimore, MD 21287, USA. Electronic address: .
Public health (Impact Factor: 1.43). 02/2013; 127(3). DOI: 10.1016/j.puhe.2012.12.030
Source: PubMed


Varying levels of evidence exist for the contribution of indoor air pollution and environmental tobacco smoke as a risk factor for tuberculosis (TB). Despite a similar mechanism of action, the influence of outdoor air pollution exposure as an independent contributor to TB disease has yet to be explored. This area of inquiry is of increasing importance given the level of pollution in the rising economies of many TB-endemic nations. Los Angeles' unique physical environs and traffic patterns mirror other global megacities with a greater burden of TB therefore allowing for preliminary correlative studies. This preliminary study hypothesizes that individuals who reside proximal to elevated pollutant exposures are likely to have a greater burden of disease – as evidenced by sputum smear-positive TB.

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