A comparison of the Cambridge Automated Neuropsychological Test Battery (CANTAB) with "traditional" neuropsychological testing instruments.
ABSTRACT The Cambridge Neuropsychological Test Automated Battery (CANTAB) is frequently used in research protocols and increasingly in clinical practice. Despite the frequency of its use, important aspects of its measurement validity have yet to be established in healthy adults. Two hundred and fifty-five individuals completed the CANTAB and traditional neuropsychological tests commonly used in clinical practice, including selected subtests from the Wechsler Adult Intelligence Scale, Controlled Oral Word Association Test, Animal Naming, Trail Making Tests A and B, the Stroop test, and the Green Story Recall test. Results showed that CANTAB subtests were modestly correlated with traditional subtests. Correlations between CANTAB subtests and traditional subtests were less consistent when age and education were controlled for. In conclusion, the CANTAB shows modest associations with traditional neuropsychological test measures.
- SourceAvailable from: Mohammad Ali Salehinejad[Show abstract] [Hide abstract]
ABSTRACT: Recent studies on major depression have used non-invasive brain stimulation techniques such as transcranial direct current stimulation to improve impaired emotion and cognition in MD. However, such experiments have yielded mixed results specifically with respect to cognition in MD. This study aimed to investigate whether anodal and cathodal tDCS applied over dorsolateral prefrontal cortex (DLPFC), would significantly improve visual working memory and reduce depressive symptoms in patients with MD. Thirty (N=30) patients with major depression were randomly assigned to receive either experimental (active) or control (sham) tDCS. Participants underwent a series of visual memory neuropsychological tasks and Beck Depression Inventory (BDI) and Hamilton Depression Scale (HDRS). After 10 sessions of anodal and cathodal tDCS, patients showed improved performance in visual working memory tasks. Specifically, active stimulation improved visual memory performance for the experimental group relative to baseline, whereas sham stimulation did not differentiate performance from baseline in the control group.NeuroRegulation 04/2015; 2(1):37-49. DOI:10.15540/nr.2.1.37
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ABSTRACT: An individual’s neurodevelopmental and cognitive sequelae to negative early experiences may, in part, be explained by genetic susceptibility. We examined whether extreme differences in the early caregiving environment, defined as exposure to severe psychosocial deprivation associated with institutional care compared to normative rearing, interacted with a biologically informed genoset comprising BDNF (rs6265), COMT (rs4680), and SIRT1 (rs3758391) to predict distinct outcomes of neurodevelopment at age 8 (N = 193, 97 males and 96 females). Ethnicity was categorized as Romanian (71%), Roma (21%), unknown (7%), or other (1%). We identified a significant interaction between early caregiving environment (i.e., institutionalized versus never institutionalized children) and the a priori defined genoset for full-scale IQ, two spatial working memory tasks, and prefrontal cortex gray matter volume. Model validation was performed using a bootstrap resampling procedure. Although we hypothesized that the effect of this genoset would operate in a manner consistent with differential susceptibility, our results demonstrate a complex interaction where vantage susceptibility, diathesis stress, and differential susceptibility are implicated.International Journal of Behavioral Development 06/2014; 39(2). DOI:10.1177/0165025414538557 · 1.58 Impact Factor
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ABSTRACT: This study presents a cross-sectional examination of the age-related executive changes in a sample of adults with a history of psychiatric illness using the Cambridge Neuropsychological Test Automated Battery. A total of 406 patients, aged 18 to 72 years old, completed executive function tests of working memory, strategic planning, and set shifting. Using current Diagnostic and Statistical Manual for Mental Disorders-Fourth Edition criteria, patients were diagnosed with: (a) affective disorders (N = 153), (b) substance-related disorders (N = 112), (c) personality disorders (N = 82), or (d) pervasive developmental disorders (N = 59). Test performances were compared to those of 52 healthy adults. Similar rates of age-related executive decline were found for patients and healthy participants. However, as adults with a history of psychiatric illness started out with significantly lower baseline levels of executive functioning, they may require less time before reaching a critical threshold where functional deficits emerge. Limitations as well as implications for future research were discussed.Applied Neuropsychology: Adult 07/2014; 21(3):210-219. DOI:10.1080/09084282.2013.793191 · 1.32 Impact Factor