When Direct Health-Care Professional Communications Have an Impact on Inappropriate and Unsafe Use of Medicines

Department of Marketing, University of Groningen, Groningen, The Netherlands.
Clinical Pharmacology &#38 Therapeutics (Impact Factor: 6.85). 12/2012; 93(4). DOI: 10.1038/clpt.2012.262
Source: PubMed

ABSTRACT Serious safety issues relating to drugs are communicated to health-care professionals via Direct Health-Care Professional Communications (DHPCs). We explored which characteristics determined the impact of DHPCs issued in the Netherlands for ambulatory-care drugs (2001-2008). With multiple linear regression, we examined the impact on the relative change in new drug use post-DHPC of the following: time to DHPC, trend in use, degree of innovation, specialist drug, first/repeated DHPC, DHPC template, and type of safety issue. DHPCs have less impact on use of specialist drugs than nonspecialist drugs (P < 0.05). The DHPCs' impact increased after availability of a template emphasizing the main problem (P < 0.05), and for safety issues with a risk of death and/or disability (both P < 0.05) (adjusted R² = 0.392). Risk communication can be effective, specifically in case of well-structured information, and very serious safety issues. Effectiveness may improve by tailoring DHPCs and adding other communication channels, for example for drugs that are increasingly being used.Clinical Pharmacology & Therapeutics (2013); advance online publication 27 February 2013. doi:10.1038/clpt.2012.262.

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Sep 25, 2014