Apolipoprotein E gene polymorphism and polycystic ovary syndrome patients in Western Anatolia, Turkey

Department of Endocrinology and Metabolism Disease, Division of Internal Medicine, Ege University Hospital, Izmir, Turkey.
Journal of Assisted Reproduction and Genetics (Impact Factor: 1.72). 01/2009; 26(1):1-6. DOI: 10.1007/s10815-008-9280-8
Source: PubMed


Dyslipidemia, cardiovascular disease and hypertension are more frequently seen in patients with PCOS than in normal patients. We aimed at evaluating the distribution of Apo E alleles that can influence cardiovascular risk of the PCOS patients and control subjects.
In this study, 129 young women with PCOS and 91 healthy women were included. In all subjects we performed hormonal, biochemical and Apo E genetic analysis.
The Apo E3 allele was found at a significantly higher frequency in the PCOS patient group compared with the control group. The Apo E2 allele was found at a significantly higher frequency in the control group compared with the patient group with PCOS.
Although there were genotype and allele differences between control and patient groups in this study, no statistically significant change was determined in lipid and other cardiovascular risk factors in connection with allele and genotype.

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    • "IR and compensatory hyperinsulinemia are considered to be main responsible for the lipidemic aberrations of obesity and PCOS. Besides, genetic factors may also contribute to the formation of dyslipidemia in PCOS disease [33]. Members of the ATP-binding cassette (ABC) transporter family, such as ABCA1, have been shown to control cellular lipid metabolism [34,35]. "
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