Upper Lobe–Predominant Diseases of the Lung

Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02115.
American Journal of Roentgenology (Impact Factor: 2.73). 03/2013; 200(3):W222-37. DOI: 10.2214/AJR.12.8961
Source: PubMed
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    • "Formalin is an effective tuberculocidal but a granuloma , a mass of inflamed granulation tissue, can deter the penetration of embalming fluid into these sites (Best et al., 1990; Demiry € urek et al., 2002; Nemec et al., 2013). MTB is an aerobic bacterium and therefore proliferates in areas of a high oxygen tension such as the lung apex (Nemec et al., 2013). There also seem to be a lack of guidelines for the effective and safe handling of formalin-fixed autopsy tissue that has been infected by MTB. "
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    ABSTRACT: Anatomy and mortuary technical staff faces an ever existing risk of contracting an infectious disease, such as Mycobacterium tuberculosis (MTB), when exposed to human remains. The transfer and handling of a corpse expels air from the lungs of the diseased and this aerosolizes the bacilli. It is for this reason that personal protective equipment and work space precautions such as ultraviolet germicidal irradiation is a necessity. In this study, the authors explore the viability of MTB before and after embalming. Briefly, lung tissue samples, both apical and hilar, were obtained from 20 cadavers whose death certificate indicated MTB as cause of death. The first sample was taken before embalming and second set 3 weeks after embalming. Tissue was deposited into sterile specimen containers and transported for analysis which included Mycobacterium growth indicator tube cultures and polymerase chain reaction. Results demonstrated that both the apical and the perihilar sample tested positive prior to embalming, 36 days after death. After three weeks post-embalming none tested positive. The results demonstrated that MTB can remain viable after death for up to 36 days. This viability extends beyond the documented cases and highlights the need for precautionary measures and standard operating procedures in accordance with occupational health and safety guidelines. Clin. Anat., 2013. © 2013 Wiley Periodicals, Inc.
    Clinical Anatomy 04/2014; 27(3). DOI:10.1002/ca.22355 · 1.33 Impact Factor
  • American Journal of Roentgenology 04/2013; 200(4):712-28. DOI:10.2214/AJR.12.9253 · 2.73 Impact Factor
  • American Journal of Roentgenology 09/2013; 201(3):W518. DOI:10.2214/AJR.13.10843 · 2.73 Impact Factor
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