Article

Unbalanced neuronal circuits in addiction

National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address: .
Current opinion in neurobiology (Impact Factor: 6.77). 02/2013; 23(4). DOI: 10.1016/j.conb.2013.01.002
Source: PubMed

ABSTRACT Through sequential waves of drug-induced neurochemical stimulation, addiction co-opts the brain's neuronal circuits that mediate reward, motivation to behavioral inflexibility and a severe disruption of self-control and compulsive drug intake. Brain imaging technologies have allowed neuroscientists to map out the neural landscape of addiction in the human brain and to understand how drugs modify it.

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