Hand-held based near-infrared optical imaging devices: a review.
ABSTRACT Near-infrared (NIR) optical imaging is a non-invasive and non-ionizing modality that is emerging as a diagnostic/prognostic tool for breast cancer and other applications related to functional brain mapping. In recent years, hand-held based optical imaging devices are developed for clinical translation of the technology, as opposed to the various bulky optical imagers available. Herein, we review the different hand-held based NIR devices developed to date, in terms of the measurement techniques implemented (continuous wave, time or frequency-domain), the imaging methods used, and the specific applications towards which they were applied. The advantages and disadvantages of the different hand-held optical devices are described and also compared with respect to a novel hand-held based device currently developed in our Optical Imaging Laboratory towards three-dimensional tomography studies.
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ABSTRACT: A novel Gen-2 hand-held optical imager was developed with capabilities to contour to different tissue curvatures, perform simultaneous illumination and detection and imager large tissue surfaces. Experimental studies using cubical phantoms demonstrated that the imager can detect targets up to 2.5 cm and 5 cm deep via reflectance and transmission measurements, respectively. The target was also localized as regions of high absorption during multi-scan imaging of curved breast phantoms via both reflectance and transmission modes. Preliminary in-vivo breast imaging demonstrated that the target can be detected via varying the pressure applied during imaging, as observed from reflectance-based imaging studies on healthy adults with superficially placed target(s) in the intra-mammary fold.Conference on Optical Tomography and Spectroscopy of Tissue X; 03/2013
Conference Paper: Resolution Studies of a Hand-Held Optical Imager[Show abstract] [Hide abstract]
ABSTRACT: A Gen-2 hand-held optical imager has been developed capable of 2D surface imaging and 3D tomography. In the current work, the capability of the imager to resolve two closely placed targets is assessed via 2D and 3D tomographic studies. Resolution studies have been carried out under various experimental conditions using slab phantoms. Preliminary 2D surface images of reflected measurements have demonstrated the ability of the system to resolve 0.95cm diameter targets placed 0.5cm apart at 2cm depth. Three dimensional tomography reconstructions are currently performed to assess the resolution capacity under different experimental conditions.Conference on Optical Tomography and Spectroscopy of Tissue X; 03/2013
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ABSTRACT: Three simple and low-cost configurations of handheld scanning probes for optical coherence tomography have been developed. Their design and testing for dentistry applications are presented. The first two configurations were built exclusively from available off-the-shelf optomechanical components, which, to the best of our knowledge, are the first designs of this type. The third configuration includes these components in an optimized and ergonomic probe. All the designs are presented in detail to allow for their duplication in any laboratory with a minimum effort, for applications that range from educational to high-end clinical investigations. Requirements that have to be fulfilled to achieve configurations which are reliable, ergonomic-for clinical environments, and easy to build are presented. While a range of applications is possible for the prototypes developed, in this study the handheld probes are tested ex vivo with a spectral domain optical coherence tomography system built in-house, for dental constructs. A previous testing with a swept source optical coherence tomography system has also been performed both in vivo and ex vivo for ear, nose, and throat-in a medical environment. The applications use the capability of optical coherence tomography to achieve real-time, high-resolution, non-contact, and non-destructive interferometric investigations with micrometer resolutions and millimeter penetration depth inside the sample. In this study, testing the quality of the material of one of the most used types of dental prosthesis, metalo-ceramic is thus demonstrated.Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine 08/2014; 228(8). DOI:10.1177/0954411914543963 · 1.14 Impact Factor