Hand-held based near-infrared optical imaging devices: A review

Optical Imaging Laboratory, Department of Biomedical Engineering, Florida International University, Miami, FL 33174, United States.
Medical Engineering & Physics (Impact Factor: 1.83). 06/2009; 31(5):495-509. DOI: 10.1016/j.medengphy.2008.10.004
Source: PubMed


Near-infrared (NIR) optical imaging is a non-invasive and non-ionizing modality that is emerging as a diagnostic/prognostic tool for breast cancer and other applications related to functional brain mapping. In recent years, hand-held based optical imaging devices are developed for clinical translation of the technology, as opposed to the various bulky optical imagers available. Herein, we review the different hand-held based NIR devices developed to date, in terms of the measurement techniques implemented (continuous wave, time or frequency-domain), the imaging methods used, and the specific applications towards which they were applied. The advantages and disadvantages of the different hand-held optical devices are described and also compared with respect to a novel hand-held based device currently developed in our Optical Imaging Laboratory towards three-dimensional tomography studies.

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    ABSTRACT: To understand Working of Human Brain measurements related to the brain function are required. These measurements should be possibly non-invasive. Brain should be disturbed as less as possible during the measurement. Integration of various modalities plays a vital role in understanding the cognitive and the behavioral changes in the human brain. It is an important source of converging evidence about specific aspects of neural functions and dysfunctions under certain pathological conditions. Focal changes in cortical blood flow are tightly coupled with the changes in neuronal activity. This constitutes the option to map the hemodynamic response and infer principles of the cortical processing, even of complex tasks. The very high temporal resolution of EEG and good spatial resolution by NIRS make this concurrent measurement unique to study the spatio-temporal dynamics of large scale neuronal networks in the human brain. Such integration of two techniques will help to overcome the limitations of a specific method. Such as insensitivity of electroencephalogram (EEG) to unsynchronized neural events or lack of near infrared spectroscopy (NIRS) to low metabolic demand. A combination of EEG and NIRS will be more informative than the two separate analyses in both modalities.
    International Journal of Computer Applications 07/2013; 63(5). DOI:10.5120/10464-5175
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    • "The hand-held probe of the Gen-2 optical imager is a forked probe design capable of conforming to tissue surface areas with minimal compression (see Figure 1(A)). The forked probe design allows for both reflectance as well as transillumination imaging approach, unlike all other hand-held imaging systems that are capable of only reflectance imaging [1–22]. There are 3 sources on each of the forked probe head, configured such that there is maximum area of illumination of the imaged region by the 4 × 5 cm2 probe head [26]. "
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    ABSTRACT: Hand-held near-infrared (NIR) optical imagers are developed by various researchers towards non-invasive clinical breast imaging. Unlike these existing imagers that can perform only reflectance imaging, a generation-2 (Gen-2) hand-held optical imager has been recently developed to perform both reflectance and transillumination imaging. The unique forked design of the hand-held probe head(s) allows for reflectance imaging (as in ultrasound) and transillumination or compressed imaging (as in X-ray mammography). Phantom studies were performed to demonstrate two-dimensional (2D) target detection via reflectance and transillumination imaging at various target depths (1-5 cm deep) and using simultaneous multiple point illumination approach. It was observed that 0.45 cc targets were detected up to 5 cm deep during transillumination, but limited to 2.5 cm deep during reflectance imaging. Additionally, implementing appropriate data post-processing techniques along with a polynomial fitting approach, to plot 2D surface contours of the detected signal, yields distinct target detectability and localization. The ability of the gen-2 imager to perform both reflectance and transillumination imaging allows its direct comparison to ultrasound and X-ray mammography results, respectively, in future clinical breast imaging studies.
    Sensors 12/2012; 12(2):1885-97. DOI:10.3390/s120201885 · 2.25 Impact Factor
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    • "Much further work in this respect is needed. Regarding detection systems, it would be ideal to have a hand-held device [17] to image sacroiliac joints and spine in the rheumatology clinic. The in vivo molecular imaging could shorten the time required to diagnose AS. "
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