Article

Lipoprotein lipase 1595 c/g and hepatic lipase -480 c/t polymorphisms--impact on lipid profile in incident dialysis patients.

Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Technology and Intervention, Karolinska Institutet, Stockholm, Sweden.
Blood Purification (impact factor: 2.1). 01/2009; 26(6):555-60. DOI:10.1159/000178772 pp.555-60
Source: PubMed

ABSTRACT Dyslipidemia is a common complication of chronic kidney disease. Lipoprotein lipase (LPL) 1595 C/G and hepatic lipase (HL) -480 C/T single nucleotide polymorphisms (SNPs) influence lipid profile and predisposition for cardiovascular disease in the general population. The present study was undertaken to clarify the impact of the two polymorphisms on lipid parameters and cardiovascular risk in incident dialysis patients.
LPL 1595 C/G and HL -480 C/T SNPs were evaluated in 293 chronic kidney disease patients close to dialysis initiation. Associations with lipid parameters, presence of cardiovascular disease, and survival were assessed.
LPL 1595 C/G SNP was associated with significantly lower triglyceride levels [1.55 (1.00-2.20) vs. 1.90 (1.40-2.48) mM; p < 0.01], while HL -480 C/T polymorphism was associated with increased high density lipoprotein cholesterol concentration [1.30 (1.00-1.60) vs. 1.10 (0.90-1.40) mM; p < 0.05]. Neither of the polymorphisms showed any relationship with patient survival.
LPL 1595 C/G and HL -480 C/T polymorphisms affect lipid profile in incident dialysis patients.

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Keywords

293 chronic kidney disease patients
 
cardiovascular risk
 
chronic kidney disease
 
clarify
 
common complication
 
density lipoprotein cholesterol concentration [1.30
 
dialysis initiation
 
Dyslipidemia
 
general population
 
hepatic lipase
 
HL -480 C/T polymorphism
 
HL -480 C/T polymorphisms
 
incident dialysis patients
 
lipid parameters
 
lipid profile
 
Lipoprotein lipase
 
lower triglyceride levels [1.55
 
patient survival
 
polymorphisms
 
two polymorphisms