Article

A 6-month randomized controlled trial to test the efficacy of a lifestyle intervention for weight gain management in schizophrenia.

BMC Psychiatry (Impact Factor: 2.23). 02/2013; 13(1):60. DOI: 10.1186/1471-244X-13-60
Source: PubMed

ABSTRACT BACKGROUND: Patients with schizophrenia have lower longevity than the general population as a consequence of a combination of risk factors connected to the disease, lifestyle and the use of medications, which are related to weight gain. METHODS: A multicentric, randomized, controlled-trial was conducted to test the efficacy of a 12-week group Lifestyle Wellness Program (LWP). The program consists of a one-hour weekly session to discuss topics like dietary choices, lifestyle, physical activity and self-esteem with patients and their relatives. Patients were randomized into two groups: standard care (SC) and standard care plus intervention (LWP). Primary outcome was defined as the weight and body mass index (BMI). RESULTS: 160 patients participated in the study (81 in the intervention group and 79 in the SC group). On an intent to treat analysis, after three months the patients in the intervention group presented a decrease of 0.48kg (CI95% -0.65 to 1.13) while the standard care group showed an increase of 0.48kg (CI95% 0.13 to 0.83; p=0.055). At six-month follow-up, there was a significant weight decrease of -1.15kg, (CI95% -2.11 to 0.19) in the intervention group compared to a weight increase in the standard care group (+0.5kg, CI95% -0.42--1.42, p=0.017). CONCLUSION: In conclusion, this was a multicentric randomized clinical trial with a lifestyle intervention for individuals with schizophrenia, where the intervention group maintained weight and presented a tendency to decrease weight after 6 months. It is reasonable to suppose that lifestyle interventions may be important long-term strategies to avoid the tendency of these individuals to increase weight.Clinicaltrials.gov identifier: NCT01368406.

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    ABSTRACT: Overweight and obesity are generally found among patients with schizophrenia. This may lead to serious implications for health and wellbeing. The aim was to review controlled intervention studies on reducing overweight/obesity and/or reducing physical illness in patients with schizophrenia. A systematic literature search was carried out in the bibliographic databases PubMed (MEDLINE), Embase (Ovid), PsycInfo (Ovid) and Cinahl (Ebsco). We included all randomised and non-randomised clinically controlled studies that compared a non-pharmacological intervention, aimed at weight reduction and/or reducing physical illness, with standard care for patients with schizophrenia. All 1713 references were evaluated for inclusion in the review. Twenty-three met the inclusion criteria and were categorised into four subgroups according to tested interventions: diet, exercise and cognitive behavioural therapy, or mixed combinations of the three. In this review, interventions showed efficacy in reducing weight and improving physical health parameters confirming that physical health improvement was possible in patients with schizophrenia. The included studies indicate that the interventions reduced weight and improved physical health parameters in patients with schizophrenia.
    Acta Psychiatrica Scandinavica 01/2014; · 4.86 Impact Factor

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May 31, 2014