A Cool Way to Live Long

The Scripps Research Institute, Department of Chemical Physiology, La Jolla, CA 92037, USA. Electronic address: .
Cell (Impact Factor: 32.24). 02/2013; 152(4):671-2. DOI: 10.1016/j.cell.2013.01.050
Source: PubMed


In this issue, Xiao et al. challenge the notion that cold temperatures promote longevity solely through thermodynamic effects. They show that low temperatures activate a cold-sensitive cation channel, TRPA-1, which triggers a complex signaling pathway in both neurons and nonneuronal cells to extend the lifespan of Caenorhabditis elegans.

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