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Malignant Pleural Mesothelioma: Update on Treatment Options with a Focus on Novel Therapies

Section of Interventional Pulmonology and Thoracic Oncology, Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Medical Center, 833 West Gates Building, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA.
Clinics in chest medicine (Impact Factor: 2.17). 03/2013; 34(1):99-111. DOI: 10.1016/j.ccm.2012.12.005
Source: PubMed

ABSTRACT There is evidence that improved treatments of malignant pleural mesothelioma are increasing the quality and quantity of life for patients with mesothelioma. Multimodality treatment programs that combine maximal surgical cytoreduction with novel forms of radiation therapy and more effective chemotherapy combinations may offer significant increases in survival for certain subgroups of patients with mesothelioma. Lung-sparing surgery may allow improvements in pulmonary function after surgery-based multimodality therapy, and potential longer overall survival than that seen with extrapleural pneumonectomy. Experimental treatments provide hope for all patients with mesothelioma, and in the future may be combined with standard therapy in multimodality protocols.

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    • "Malignant mesothelioma (MM) originates from the thin monolayer of mesothelial cells, lining the body cavities and surface of internal organs. It can arise in the pleural cavity, peritoneal cavity, pericardial cavity or tunica vaginalis, but pleural cavity is most frequently involved (~80%) [1]. A study based on WHO mortality database reported a death toll of 92,253 from MM within 1994-2008 in 83 countries [2] and global cases of MM are projected to be on the rise for decades to come [3]. "
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