Phosphodiesterase Type 5 Inhibitors Improve Endothelial Function and May Benefit Cardiovascular Conditions

Heart Institute, Good Samaritan Hospital, Los Angeles, Calif.
The American journal of medicine (Impact Factor: 5). 03/2013; 126(3):192-9. DOI: 10.1016/j.amjmed.2012.08.015
Source: PubMed


The effects of phosphodiesterase type 5 inhibitors on vasodilation mediated via nitric oxide-cyclic guanosine monophosphate are well described. Less is known about other mechanisms through which phosphodiesterase type 5 inhibitors benefit endothelial function, including normalization of serum biomarkers, increased levels of endothelial progenitor cells, ischemia-reperfusion protection mechanisms, and other actions specific to patients with diabetes. These various mechanisms are reviewed. Their impact on several cardiovascular diseases, including erectile dysfunction, pulmonary hypertension, heart failure, high-altitude pulmonary edema, Raynaud's phenomenon, coronary artery disease, diabetes, and atherosclerosis, is presented.

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    • "Although the etiology of DM-induced ED is multifactorial and still unknown, endothelial dysfunction is thought to be one of the key factors. Patients with DM and ED often have severe endothelial dysfunction and respond poorly to oral phosphodiesterase (PDE)5 inhibitors [2]. Tadalafil is a PDE5 inhibitor that is safe and efficacious for treating ED across a variety of clinical populations, including patients with many risk factors [3]. "
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