Wang, C.-C., Yan, S., Yao, C., Huang, X.-Y., Ao, X. & Wang, Z. et al. Ancient DNA of emperor CAO Cao's granduncle matches those of his present descendants: a commentary on present Y chromosomes reveal the ancestry of Emperor CAO Cao of 1800 years ago. J. Hum. Genet. 58, 238-239

State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Department of History, Fudan University, Shanghai, China.
Journal of Human Genetics (Impact Factor: 2.46). 02/2013; 58(4). DOI: 10.1038/jhg.2013.5
Source: PubMed


Journal of Human Genetics, official journal of the Japan Society of Human Genetics, publishes original articles and reviews on all aspects of human genetics, including medical genetics and genomics

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Available from: Chuan-Chao Wang,
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    • "First is the pedigree-based analysis, we can collect and sequence some reliable deep-rooting pedigrees representing a broad spectrum of worldwide Y chromosomal lineages or at least common haplogroups of East Asia. Recording the family trees has been a religious tradition of Han Chinese, and some family trees even span more than 100 generations, linking the contemporary individuals to their ancestors over 2 to 3 kya, although their authenticity requires careful validation [29,30]. More reliable deep-rooting pedigrees could overcome the possible bias in rate estimation caused by previous one single pedigree and only four mutations as we have discussed above. "
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    ABSTRACT: Y chromosome is a superb tool for inferring human evolution and recent demographic history from a paternal perspective. However, Y chromosomal substitution rates obtained using different modes of calibration vary considerably, and have produced disparate reconstructions of human history. Here, we discuss how substitution rate and date estimates are affected by the choice of different calibration points. We argue that most Y chromosomal substitution rates calculated to date have shortcomings, including a reliance on the ambiguous human-chimpanzee divergence time, insufficient sampling of deep-rooting pedigrees, and using inappropriate founding migrations, although the rates obtained from a single pedigree or calibrated with the peopling of the Americas seem plausible. We highlight the need for using more deep-rooting pedigrees and ancient genomes with reliable dates to improve the rate estimation.
    Investigative Genetics 08/2014; 5(12). DOI:10.1186/2041-2223-5-12
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    • "Ancient DNA extracted from a tooth of Cao Cao’s grand-uncle also supported the conclusion drawn from the present Y chromosomes that the haplogroup of Emperor Cao was O2*-M268. Emperor Cao’s father was most probably adopted from his grandfather’s own clan rather than from beggardom [61]. "
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    ABSTRACT: East Asia harbors substantial genetic, physical, cultural and linguistic diversity, but the detailed structures and interrelationships of those aspects remain enigmatic. This question has begun to be addressed by a rapid accumulation of molecular anthropological studies of the populations in and around East Asia, especially by Y chromosome studies. The current Y chromosome evidence suggests multiple early migrations of modern humans from Africa via Southeast Asia to East Asia. After the initial settlements, the northward migrations during the Paleolithic Age shaped the genetic structure in East Asia. Subsequently, recent admixtures between Central Asian immigrants and northern East Asians enlarged the genetic divergence between southern and northern East Asia populations. Cultural practices, such as languages, agriculture, military affairs and social prestige, also have impacts on the genetic patterns in East Asia. Furthermore, application of Y chromosome analyses in the family genealogy studies offers successful showcases of the utility of genetics in studying the ancient history.
    Investigative Genetics 06/2013; 4(1):11. DOI:10.1186/2041-2223-4-11
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    ABSTRACT: Sayyid Ajjal is the ancestor of many Muslims in areas all across China. And one of his descendants is the famous Navigator of Ming Dynasty, Zheng He, who led the largest armada in the world of 15th century. The origin of Sayyid Ajjal's family remains unclear although many studies have been done on this topic of Muslim history. In this paper, we studied the Y chromosomes of his present descendants, and found they all have haplogroup L1a-M76, proving a southern Persian origin.
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