Sjogren's syndrome presenting with hypokalemic periodic paralysis

Department of Medicine, Sir J.J. Group of Hospitals, Byculla, Mumbai.
The Journal of the Association of Physicians of India 07/2012; 60(7):55-6.
Source: PubMed


We report a rare case of a 38-year-old female who presented with sudden onset flaccid quadriplegia and respiratory arrest with no significant past clinical history. She was later found to have hypokalemia due to distal renal tubular acidosis and further diagnosed as case of Sjogrens Syndrome.

15 Reads
  • Source
    Nephrology Dialysis Transplantation 02/1994; 9(8):1176-8. · 3.58 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: A 38-year-old woman presented to the emergency department with rapidly progressive quadriparesis. The patient reported sudden onset of diffuse myalgias associated with generalized muscular weakness and numbness during the last week. On the day prior to admission, paresis of limb and neck muscles developed. She denied any sensory, sphincter, visual, respiratory, or language disturbance. There was no history of recent gastrointestinal or respiratory upset. She denied diuretic, laxative or excessive licorice intake. There were no recent vaccinations, she had never experienced a similar event in the past, and there was no significant family history. She did not smoke or drink alcohol. She gave a history of joint pain associated with morning stiffness and Raynaud-like symptoms at her hands for several years. Hypothyroidism developed subacutely as a consequence of post-partum autoimmune thyroiditis after her first pregnancy, when the patient was 30 years old, and levothyroxine treatment had been started. Mild-grade proteinuria (\500 mg/die) had been detected during a biochemical assessment in the beginning of her second pregnancy last year. Also laboratory testing revealed a hypokalemia of 2.8 mEq/L. She had a history of calcium oxalate nephrolithiasis treated with lithotripsy. On admission, physical examination revealed no disturbances of consciousness or cognition; she was hemodynamically stable, the body temperature was 36.6C, the recumbent blood pressure 120/80 mmHg, the pulse rate 70 beats per minute with regular sinus rhythm, and the respiratory rate 20 breaths per minute. Finger pulse oximetry revealed 98% arterial oxygen saturation and blood glucose concentration measured by a portable meter was 102 mg/dL. Lung fields were clear, and heart sounds were normal. The cranial nerve examination was unremarkable. Head flexion and extension were mildly weak. Motor examination demon
    Internal and Emergency Medicine 07/2008; 3(2):175-7. DOI:10.1007/s11739-008-0106-6 · 2.62 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A 16-year-girl, a known case of hyperthyroidism since last 6 months, presented to the emergency with complaints of acute gastroenteritis of 5 days duration. At admission the child was found to be hypovolemic with acidotic breathing, which was thought to be due to dehydration. However, despite fluid correction she remained acidotic. A diagnosis of distal renal tubular acidosis (RTA) was suspected when her renal scan, for the cause of metabolic acidosis, revealed nephrocalcinosis. This was later confirmed by relevant investigations. She was started on treatment for distal RTA on which she symptomatically improved. The association of distal RTA and thyroid disorders is rarely reported in children. Till date there is only one report of distal RTA and hypothyroidism, but none with hyperthyroidism in this age group. The authors chose to report this case to highlight the fact that one should have a high index of suspicion for renal tubular disorders in children with thyroid hormone abnormalities, as these are treatable conditions if diagnosed early.
    The Indian Journal of Pediatrics 05/2011; 79(2):260-1. DOI:10.1007/s12098-011-0482-1 · 0.87 Impact Factor
Show more


15 Reads
Available from