Characteristics of B-Cell Lymphomas in HIV/HCV-Coinfected Patients During the Combined Antiretroviral Therapy Era

1Department of Internal Medicine II 2Department of Internal Medicine I 3INSERM U943 4Université Paris 6 Pierre et Marie Curie UMR S 943, F-75013, Paris 5Department of Pathology, Hôpital Antoine Béclère, AP-HP, Clamart 6Université Paris-Sud, UFR Médecine, Le Kremlin-Bicêtre, F-94275 7Hematology and Immunology department 8Inserm U-1012, Le Kremlin-Bicêtre, F-94275 9Department of Hematology, Hôpital La Conception, Marseille 10Department of Infectious Diseases, AP-HP, le Kremlin-Bicêtre, F-94275 11Department of Hematology, Groupe Hospitalier Pitié-Salpétrière, AP-HP, F-75013 12Department of Hematology, Centre Hospitalier Sud-Francilien, Corbeil-Essonne 13Department of Infectious Diseases, CHU, Vandoeuvre Les Nancy 14Department of Hematology and 15Department of Infectious Diseases, CHU, Nantes 16Department of Pathology 17Department of Hematology, APHP, Hôpital Necker-Enfants Malades, Paris F-75015 18CNRS UMR 8126, IGR, Villejuif F-94800.
JAIDS Journal of Acquired Immune Deficiency Syndromes (Impact Factor: 4.39). 02/2013; 63(2). DOI: 10.1097/QAI.0b013e31828a77f0
Source: PubMed

ABSTRACT Hepatitis C virus (HCV) infection is frequent among HIV infected patients. We describe the characteristics of 6 HIV-HCV coinfected patients with B-cell non-Hodgkin lymphoma (NHL) included in a prospective cohort study of HIV related lymphomas. Five of the six cases had features of marginal zone/lymphoplasmacytic NHL versus one out of 33 HIV only infected patients. Remarkably, anti-HCV treatment led to a hematological response in a patient with splenic marginal zone lymphoma. This supports the role of chronic antigenic stimulation by HCV on lymphomagenesis and further evaluation of HCV antiviral therapy in coinfected patients with NHL.