Clinical and biochemical effects of coenzyme Q10, vitamin E, and selenium supplementation to psoriasis patients

Immunology Department, Medical University, Nal'chik, Russian Federation.
Nutrition (Impact Factor: 3.05). 12/2008; 25(3):295-302. DOI: 10.1016/j.nut.2008.08.015
Source: PubMed

ABSTRACT The aim of the present study was to evaluate clinical effects of supplementation with antioxidants to patients with severe erythrodermic (EP) and arthropathic (PsA) forms of psoriasis.
Fifty-eight patients were hospitalized, treated by conventional protocols, and randomly assigned to four groups. Groups EP1 and PsA1 were supplemented with coenzyme Q(10) (ubiquinone acetate, 50 mg/d), vitamin E (natural alpha-tocopherol, 50 mg/d), and selenium (aspartate salt, 48 mug/d) dissolved in soy lecithin for 30-35 d. Groups EP2 and PsA2 (placebo) received soy lecithin. Clinical conditions were assessed by severity parameters. Markers of oxidative stress included superoxide production, copper/zinc-superoxide dismutase, and catalase activities in the circulating granulocytes, in the affected epidermis, and plasma levels of nitrites/nitrates.
At baseline patients had an increased superoxide release from granulocytes (10.0 +/- 0.5, 2.9 +/- 0.2, and 1.5 +/- 0.1 nmol/L per 10(6) cells/h for EP, PsA, and donors, respectively), increased copper/zinc-superoxide dismutase and catalase activities in granulocytes in EP patients and decreased in PsA patients, decreased activity of copper/zinc-superoxide dismutase (0.3 +/- 0.0, 1.8 +/- 0.1, and 2.2 +/- 0.2 U/mg protein for EP, PsA, and donors, respectively), and altered activity of catalase in psoriatic epidermis. Plasma levels of nitrites/nitrates were greater than normal in psoriatic patients. Supplementation resulted in significant improvement of clinical conditions, which corresponded to the faster versus placebo normalization of the oxidative stress markers.
Supplementation with antioxidants coenzyme Q(10), vitamin E, and selenium could be feasible for the management of patients with severe forms of psoriasis.

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    • "It is considered a T-helper 1 (Th1) disease based on the increase in cytokines of the Th1 pathway such as interferon gamma, interleukin (IL) 2 and 12, as found in psoriatic plaques [2] [3]. However, a strong evidence also indicated keratinocytes contributed to the disease [7] and keratinocytes is viewed as another major player of this chronic inflammatory disease [8]. For instance, decrease in skin cells apoptosis is suggested as a specific pathogenic phenomenon in psoriasis [9] [10]. "
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    Evidence-based Complementary and Alternative Medicine 04/2013; 2013(4):792840. DOI:10.1155/2013/792840 · 1.88 Impact Factor
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    • "It is possible that coenzyme Q10 supplements do not affect glutathione concentration and GPx activity [34]. Hepatic antioxidant enzymes such as CAT and SOD play an important role in the protection of cells against oxidative stress by ameliorating superoxide anion and H 2 O 2 toxicities [35] and increasing their activity rapidly after antioxidant supplementation [36]. Notably, the activity of CAT and SOD were significantly decreased in the placebo group compared with baseline. "
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    Nutrition 03/2012; 28(3):250-5. DOI:10.1016/j.nut.2011.06.004 · 3.05 Impact Factor
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    • "For example, pharmacological behavior of avarol- 3'-thiosalicylate, a promising antipsoriatic agent, has been experimentally demonstrated to possess antioxidant properties, thus suppressing the inflammatory process (Amigo et al., 2007). Since diet has also been suggested to play a role in the aetiology and pathogenesis of psoriasis, various dietary factors showing such beneficial effects as anti-inflammatory and antioxidant properties are of great interest in the present decade (Wolters, 2005; Kharaeva et al., 2009). It has been well docu-mented that a number of patients with psoriasis show an elevated sensitivity to gluten, a food allergen. "
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    ABSTRACT: Psoriasis, a chronic inflammatory skin disease, is not yet curable, and its precise causes remain unclear. Nevertheless, several lines of evidence support that psoriasis is a multifactorial disease. Because psoriasis occurs in connection with stress and mood disorders, the genes in serotonergic system may be involved in psoriasis with regard to etiology and pathogenesis. Such molecular impacts supported by scientific evidence on serotonergic gene expression changes and genetic polymorphisms have been increasingly highlighted. The serotonergic system has also received considerable attention as a potential target for the therapy of psoriasis. Here, we summarize the current knowledge about role of genes in serotonergic system in psoriasis and point out possible directions of future studies.
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