Glucose-induced insulin secretion: nutritional prevention and novel avenues for therapy.
ABSTRACT Insulin resistance, the most important pathophysiological feature in various prediabetic and diabetic states is partly related to impaired glucose-stimulated insulin secretion and insulin modulation of pancreatic beta cell with peripheral impaired insulin response. This chapter concentrates on aspects of potential new strategies in the treatment of the disease going from nutritional preventive approaches towards currently utilized drugs for treatment that target the pancreatic beta cells with potentiation of glucose-stimulated insulin secretion.
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ABSTRACT: Diabetes mellitus (DM) affects over 10% of the world population. Hyperglycemia is the main feature for the diagnosis of this disease. The zebrafish (Danio rerio) is an established model organism to the study of various metabolic diseases. In this paper, hyperglycemic zebrafish, by immersing in a 111mM glucose solution for 14days, developed increase glycation of proteins from eyes, decrease of mRNA levels of insulin receptors in muscle, and reversion of high blood glucose level after treatment with anti-diabetic drugs (glimepiride and metformin) even after 7days of glucose withdrawal. Additionally, hyperglycemic zebrafish developed impaired response to exogenous insulin, which was recovered after 7days of glucose withdrawal. These data suggest that the exposure of adult zebrafish to high glucose concentration is able to induce persistent metabolic changes probably underlined by a hyperinsulinemic state and peripheral impaired glucose metabolism.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 04/2014; 171. DOI:10.1016/j.cbpb.2014.03.005 · 1.90 Impact Factor