COMT and ANKK1-Taq-Ia genetic polymorphisms influence visual working memory

Yale University, United States of America
PLoS ONE (Impact Factor: 3.23). 01/2013; 8(1):e55862. DOI: 10.1371/journal.pone.0055862
Source: PubMed


Complex cognitive tasks such as visual working memory (WM) involve networks of interacting brain regions. Several neurotransmitters, including an appropriate dopamine concentration, are important for WM performance. A number of gene polymorphisms are associated with individual differences in cognitive task performance. COMT, for example, encodes catechol-o-methyl transferase the enzyme primarily responsible for catabolizing dopamine in the prefrontal cortex. Striatal dopamine function, linked with cognitive tasks as well as habit learning, is influenced by the Taq-Ia polymorphism of the DRD2/ANKK1 gene complex; this gene influences the density of dopamine receptors in the striatum. Here, we investigated the effects of these polymorphisms on a WM task requiring the maintenance of 4 or 6 items over delay durations of 1 or 5 seconds. We explored main effects and interactions between the COMT and DRD2/ANKK1-Taq-Ia polymorphisms on WM performance. Participants were genotyped for COMT (Val(158)Met) and DRD2/ANKK1-Taq-Ia (A1+, A1-) polymorphisms. There was a significant main effect of both polymorphisms. Participants' WM reaction times slowed with increased Val loading such that the Val/Val homozygotes made the slowest responses and the Met/Met homozygotes were the fastest. Similarly, WM reaction times were slower and more variable for the DRD2/ANKK1-Taq-Ia A1+ group than the A1- group. The main effect of COMT was only apparent in the DRD2/ANKK1-Taq-Ia A1- group. These findings link WM performance with slower dopaminergic metabolism in the prefrontal cortex as well as a greater density of dopamine receptors in the striatum.

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Available from: H. Branch Coslett, Dec 23, 2013
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    • "In studies of young adults and children, this particular polymorphism has been associated with reduced cognitive abilities in carriers of the A-allele compared to noncarriers (Berman and Noble, 1995; Klein et al., 2007). Moreover, in line with the hypothesis that striatal DA is critical for cognitive flexibility, DRD2/ANKK1-TaqIA affects task switching and working memory-related processes (Berryhill et al., 2013; Jocham et al., 2009; Stelzel et al., 2010). It was also recently shown that the DRD2/ANKK1-TaqIA polymorphism influences updating of mental representations in epistatic interaction with the COMT Val108/158Met genotype (Garcia-Garcia et al., 2011). "
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