Granuloma annulare-like reaction to the bacillus Calmette-Guerin vaccination

Department of Dermatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, JR Osaka Hospital, Osaka, Japan.
Australasian Journal of Dermatology (Impact Factor: 1.11). 02/2013; 54(1):e4-7. DOI: 10.1111/j.1440-0960.2011.00814.x
Source: PubMed


We report the case of a 6-month-old girl with a granuloma annulare (GA)-like reaction to the bacillus Calmette-Guerin (BCG) vaccination. The eruption developed at the vaccination site 1 month after vaccination and the lesion gradually disseminated over the body within 2 months. A biopsy specimen of the skin lesion showed degenerated collagen bundles surrounded by imperfect palisading histiocytes, lymphocytes and epithelioid cells in the dermis, which led to a diagnosis of GA-like reaction as a secondary reaction to BCG inoculation. The eruption at the vaccination site and the scattered GA reaction resolved after 1 month of treatment with prednisolone valerate acetate ointment, leaving only pigmentation.

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