Article

Bioprinting Toward Organ Fabrication: Challenges and Future Trends

IEEE Transactions on Biomedical Engineering (Impact Factor: 2.23). 01/2013; DOI: 10.1109/TBME.2013.2243912
Source: PubMed

ABSTRACT Tissue engineering has been a promising field of research, offering hope for bridging the gap between organ shortage and transplantation needs. However, building three-dimensional (3D) vascularized organs remains the main technological barrier to be overcome. Organ printing, which is defined as computer-aided additive biofabrication of 3D cellular tissue constructs, has shed light on advancing this field into a new era. Organ printing takes advantage of rapid prototyping (RP) technology to print cells, biomaterials, and cell-laden biomaterials individually or in tandem, layer by layer, directly creating 3D tissue-like structures. Here, we overview RP-based bioprinting approaches and discuss the current challenges and trends towards fabricating living organs for transplant in the near future.

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