416 Impact of Exercise on Lower Activity Levels in Children with Acute Lymphoblastic Leukemia: A Randomized Controlled Trial From Turkey

Rehabilitation nursing: the official journal of the Association of Rehabilitation Nurses (Impact Factor: 1.15). 01/2013; 38(1):48-59. DOI: 10.1002/rnj.58
Source: PubMed


Background and Aims Children with Acute lymphoblastic leukemia (ALL) exhibit body function disorders and activity limitations at an early stage. A study assessing the impact of activities and health-related quality of life of initiatives physical exercise in children with ALL were not found in Turkey. This study was carried out to determine the effects of an exercise program on both physical parameters and on quality of life in children with ALL.
Methods A total of 41 children with ALL at two university hospitals were accepted into the study. Due to the demise of one of the children in the trial group, the study was completed with 19 trial and 21 control patients, a total of 40 children and their parents. The two groups were formed by randomized selection. The study was implemented in the children’s homes and in the clinical environment and in the period 2007–2008.
Results When the trial subjects were assessed in terms of their mean scores in the 9-Minute Walk Test, the Timed Up and Down Stairs Test, the Timed Up and Go Test, the measurements of their leg muscle strength, their hemoglobin and hematocrit tests, a decidedly significant increase was seen compared to the control group (p<0.05).
Conclusions Regular and systematic exercise regimens implemented by children with ALL have resulted in improved testing results, enhanced physical performance, and better laboratory results compared to a control group and to children’s scores prior to the initiation of such a program.

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    • "This impairment reduces quality of life (QoL) and increases the prevalence of morbidities, with a subsequent decrease in maximal aerobic capacity and reduced maximal strength 15. Recent studies have hypothesized that a physical fitness program following cancer treatment could positively affect additional side effects of this illnesses, such as osteoporosis or decreased muscle tone but also counteract the weight gain often associated with postcancer treatment 17–19. Chang et al. "
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    ABSTRACT: The aim of this study was to assess the fitness levels and possible deficits in physical performance in children with a diagnosis of childhood acute leukemia and lymphoma after 10 months of therapy ending through a specific test battery. A total of 58 subjects were enrolled in this study. The experimental group (EG) (7.55 ± 2.43 years; 41.8 ± 16.37 kg; 144.6 ± 10.21 cm) consisted of 18 children with diagnosed leukemia and lymphoma after completion of 10 months of therapy intervention and 40 healthy children who were enrolled in a control group (CG) (7.92 ± 1.78 years; 37.4 ± 12.37 kg; 140.6 ± 12.61 cm). A testing battery including the standing broad jump; the sit-up test; the 4 × 10 m shuttle run test, and the hand grip strength test were administered to both groups. An unpaired t-test was adopted to determine differences and the Pearson product moment was administered when appropriate. Results of the EG were generally lower when compared to the CG. Significant differences were identified for the standing broad jump (P < 0.05); 4 × 10 m shuttle run (P < 0.05); hand grip test DX (P < 0.05), and hand grip test SX (P < 0.05). No significant differences were found between the sit-up tests. Pearson product moment correlation revealed a good interaction for all EG participants. Findings suggest that the proposed testing battery could be an appropriate tool to evaluate residual fitness levels in children with previous hematological malignancies. However, our results have to be confirmed with a larger number of participants with the same diagnosis of our EG.
    Cancer Medicine 04/2014; 3(2). DOI:10.1002/cam4.193 · 2.50 Impact Factor
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    ABSTRACT: Purpose: Children with acute lymphoblastic leukemia (ALL) are at increased risk of obesity and deconditioning from cancer therapy. This pilot study assessed feasibility/initial efficacy of an exercise intervention for patients with ALL undergoing maintenance therapy. Methods: Participants were aged 5 to 10 years, receiving maintenance therapy, in first remission. A 6-month home-based intervention, with written and video instruction, was supervised with weekly calls from an exercise coach. Pre- and poststudy testing addressed strength, flexibility, fitness, and motor function. Results: Seventeen patients enrolled (participation 63%). Twelve (71%) finished the intervention, completing 81.7 ± 7.2% of prescribed sessions. Improvements of 5% or more occurred in 67% for knee and 75% for grip strength, 58% for hamstring/low-back and 83% for ankle flexibility, 75% for the 6-Minute Walk Test, and 33% for performance on the Bruininks-Oseretsky Test of Motor Proficiency Version 2. Conclusions: This pilot study demonstrated that exercise intervention during ALL therapy is feasible and has promise for efficacy. Copyright © 2014 Wolters Kluwer Health|Lippincott Williams & Wilkins and Section on Pediatrics of the American Physical Therapy Association.
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    ABSTRACT: Although people with haematological malignancies have to endure long phases of therapy and immobility which is known to diminish their physical performance level, the advice to rest and avoid intensive exercises is still common practice. This recommendation is partly due to the severe anaemia and thrombocytopenia from which many patients suffer. The inability to perform activities of daily living restricts them, diminishes their quality of life and can influence medical therapy.
    Cochrane database of systematic reviews (Online) 11/2014; 11(11):CD009075. DOI:10.1002/14651858.CD009075.pub2 · 6.03 Impact Factor
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