Carotid Artery Plaque and LDL-to-HDL Cholesterol Ratio Predict Atherosclerotic Status in Coronary Arteries in Asymptomatic Patients with Type 2 Diabetes Mellitus
To investigate the clinical predictors of coronary atherosclerosis and to assess the utility of maximum-IMT for predicting coronary atherosclerosis in asymptomatic type 2 diabetic patients.
One hundred one Japanese patients with type 2 diabetes underwent computed tomography coronary angiography. Definitions of coronary artery stenosis and vulnerable coronary plaque were luminal narrowing of ≥50% and any coronary plaque with positive vessel remodeling and low attenuation, respectively. Carotid intima-media thickness (IMT) was assessed using B-mode ultrasound.
Of the 101 patients, 40 had coronary artery stenosis without vulnerable coronary plaque, 7 had vulnerable coronary plaque without coronary artery stenosis, and 23 had coronary artery stenosis with vulnerable coronary plaque. Male sex (p=0.031), duration of diabetes (p=0.024), systolic blood pressure (SBP) (p=0.039), and the LDL/HDL ratio (LDL/HDL) (p=0.013) were independent predictors of coronary artery stenosis and the LDL/HDL (p=0.042) independently predicted vulnerable coronary plaque by logistic regression analyses. Areas under the curves in receiver operating characteristic curve analysis of the maximum-IMT, LDL/HDL, and these two parameters combined were 0.711 (95% CI 0.601-0.820), 0.618 (0.508-0.728), and 0.732 (0.632-0.831), respectively, for predicting coronary artery stenosis and 0.655 (0.537-0.773), 0.629 (0.504-0.754), and 0.710 (0.601-0.818), respectively, for predicting vulnerable coronary plaque.
Male sex, duration of diabetes, elevated SBP, and LDL/HDL were independent predictors of coronary artery stenosis. LDL/HDL was an independent predictor of vulnerable coronary plaque. Maximum-IMT predicted both coronary stenosis and vulnerable coronary plaque. Adding LDL/HDL improved the prediction of coronary artery stenosis and vulnerable coronary plaque.
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- "Increased carotid intima-media thickness (cIMT) has been proposed as a signal of subclinical atherosclerosis . cIMT is related to atherosclerotic status in patients with several cardiovascular risk factors, such as diabetes , hypertension  or dyslipidemia  . Overweight and obesity have also been related to higher cIMT  . "
ABSTRACT: Background and Aims Obesity is associated with increased cardiovascular risk. However, the impact of morbid obesity on vascular structure and function is not well understood. This study was designed to appraise subclinical atherosclerosis markers, including carotid intima media thickness (cIMT), endothelial function, and arterial wall stiffness, and their determinants, in morbidly obese patients. Methods and Results In this cross-sectional study 194 overweight and obese patients were distributed in morbid obese patients (MOP, n=110), obese (OP, n=84) and overweight patients (OwP, n=33) groups. Demography, anthropometry, clinical and standard biochemical data were recorded. cIMT, endothelial function, defined as the small artery reactivity index (saRHI), and artery wall rigidity, studied by the augmentation index, were determined. More than 50% of the MOP, OP and OwP had a cIMT above the 75th percentile per age and gender. No differences in cIMT or saRHI were observed, although OOP had higher arterial rigidity compared with the overweight and non-morbid obese group. In a multivariate regression test, while cholesterol was the main determinant of cIMT in overweight and obese patients, glucose metabolism was the determinant in MOP. Conclusion More than half of the population have a cIMT above general population ranges. OwP, OP and MOP have similar cIMT and saRHI. However, OOP have greater arterial wall rigidity. Dysglycemia is the main factor associated with subclinical atherosclerosis in MOP.Nutrition Metabolism and Cardiovascular Diseases 09/2014; 24(9). DOI:10.1016/j.numecd.2014.04.012 · 3.32 Impact Factor
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ABSTRACT: Background: It is unclear whether early physical activity has a greater influence on intima-media thickness and metabolic variables than current physical activity. Objective: To analyze the relationship between current and early physical activity, metabolic variables, and intima-media thickness measures in adults. Method: The sample was composed of 55 healthy subjects of both sexes (33 men and 22 women). Total body fat and trunk fat were estimated by dual-energy X-ray absorptiometry. Carotid and femoral intima-media thickness were measured using a Doppler ultrasound device. A 12-hour fasting blood sample collection was taken (fasting glucose and lipid profile). Early physical activity was assessed through face-to-face interview, and the current physical activity was assessed by pedometer (Digi-Walker Yamax, SW200), which was used for a period of seven days. Results: Current physical activity was negatively related to total cholesterol (rho=-0.31), while early physical activity was negatively related to triglycerides (rho=-0.42), total cholesterol (rho=-0.28), very low density lipoprotein (rho=-0.44), and carotid intima-media thickness (rho=-0.50). In the multivariate model, subjects engaged in sports activities during early life had lower values of very low density lipoprotein (b=-8.74 [b=-16.1; -1.47]) and carotid intima-media thickness (b=-0.17 [95%CI: -0.28; -0.05]). Conclusion: Early 95%CI physical activity has a significant influence on carotid intima-media thickness, regardless of the current physical activity.Revista Brasileira de Fisioterapia 08/2014; DOI:10.1590/bjpt-rbf.2014.0040 · 0.94 Impact Factor
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ABSTRACT: Purpose To evaluate the relationship of carotid artery plaque with international prostate symptom score (IPSS) and international index of erectile function-5 (IIEF). Methods We enrolled 799 men who had participated in a health examination. They received an IPSS, IIEF, a carotid duplex ultrasound, and a full metabolic work-up. Data were analyzed using Spearman’s correlation test, the Mantel–Haenszel Extension test, and logistic regression analyses. Results The median age of the study population was 57 years, and the median IPSS and IIEF were 11 and 15, respectively. The IPSS voiding sub-score was significantly correlated with maximum intima-media thickness (max IMT) (P = 0.002). We observed a significant increase in the severity of the voiding sub-score with increasing severity of plaque size (P = 0.003). Additionally, there was an increased likelihood of having a higher IPSS voiding sub-score as severity of plaque size increased after adjusting for age and components of metabolic syndrome. The IIEF showed a significant negative correlation with max IMT (PInternational Urology and Nephrology 09/2014; 46(12). DOI:10.1007/s11255-014-0830-y · 1.52 Impact Factor