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Terahertz Pulsed Imaging of skin cancer in the time and frequency domain

Cavendish Laboratory, University of Cambridge, Madingley Road, Cambridge, CB3 OHE UK.
Journal of Biological Physics (Impact Factor: 1.15). 06/2003; 29(2-3):257-9. DOI: 10.1023/A:1024409329416
Source: PubMed

ABSTRACT Terahertz Pulsed Imaging(TPI) is a new medical imaging modality forthe detection of epithelial cancers. Overthe last two years this technique has beenapplied to the study of in vitrobasal cell carcinoma (BCC). Usingtime-domain analysis the contrast betweendiseased and normal tissue has been shownto be statistically significant, andregions of increased terahertz (THz)absorption correlated well with thelocation of the tumour sites in histology.Understanding the source of this contrastthrough frequency-domain analysis mayfacilitate the diagnosis of skin cancer andrelated skin conditions using TPI. Wepresent the first frequency-domain analysisof basal cell carcinoma in vitro,with the raw power spectrum giving aninsight into the surface features of theskin. Further data manipulation is requiredto determine whether spectral informationcan be extrapolated at depth. These resultshighlight the complexity of working inreflection geometry.

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