Article

Effect of vanadium on insulin sensitivity in patients with impaired glucose tolerance.

Medical Research Unit in Clinical Epidemiology, Medical Unit of High Specialty, West National Medical Center, Mexican Institute of Social Security, Guadalajara, Mexico.
Annals of Nutrition and Metabolism (impact factor: 2.26). 12/2008; 53(3-4):195-8. DOI:10.1159/000175844 pp.195-8
Source: PubMed

ABSTRACT Impaired glucose tolerance (IGT) is considered a risk factor for developing type 2 diabetes mellitus (T2DM) and is associated with insulin resistance. Vanadium seems to block protein tyrosine phosphatase with the consequent increment in insulin sensitivity (INS) in T2DM patients, but this effect has not been studied in IGT patients. The aim of this study was to evaluate the effect of vanadium on INS in IGT patients.
A randomized, double-blind, placebo-controlled clinical trial was carried out in 14 overweight/obese patients with IGT. Intervention consisted of vanadyl sulfate (VS, 50 mg p.o. twice daily) or placebo for 4 weeks. Before and after the intervention, a metabolic profile was performed and INS was assessed using the euglycemic-hyperinsulinemic clamp technique. Mann-Whitney U and Wilcoxon rank tests were used for statistical analyses.
There were no significant differences in basal characteristics between groups. VS did not affect INS [2.7+/-0.8 vs. 2.9+/-0.9 mg/(kg/min), p=0.735] but increased triglyceride levels (1.35+/-0.61 vs. 1.70+/-0.46 mmol/l, p=0.018).
VS administration in IGT patients increased triglyceride concentrations without changes in INS.

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Keywords

14 overweight/obese patients
 
4 weeks
 
basal characteristics
 
block protein tyrosine phosphatase
 
consequent increment
 
double-blind
 
euglycemic-hyperinsulinemic clamp technique
 
IGT patients
 
Impaired glucose tolerance
 
insulin resistance
 
insulin sensitivity
 
Mann-Whitney U
 
placebo-controlled clinical trial
 
risk factor
 
statistical analyses
 
T2DM patients
 
type 2 diabetes mellitus
 
vanadium
 
vanadyl sulfate
 
Wilcoxon rank tests
 

Omar Jacques-Camarena