Article

Canthin-6-one alkaloids from Picrasma quassioides and their cytotoxic activity.

School of Pharmaceutical Science, Central South University, Changsha, China.
Journal of Asian Natural Products Research (impact factor: 0.94). 12/2008; 10(11-12):1009-12. DOI:10.1080/10286020802277956 pp.1009-12
Source: PubMed

ABSTRACT A new alkaloid, 4,5-dimethoxy-10-hydroxycanthin-6-one (1), was isolated from the stem of Picrasma quassioides Bennet (Simaroubaceae) together with four known canthin-6-one alkaloids, 8-hydroxycanthin-6-one (2), 4,5-dimethoxycanthin-6-one (3), 5-hydroxy-4-methoxycanthin-6-one (4), and 3-methylcanthin-5,6-dione (5). Their structures were elucidated on the basis of spectroscopic data. The cytotoxic activity of the canthin-6-one alkaloids was evaluated using human nasopharyngeal carcinoma (CNE2) and human liver cancer (Bel-7402) cell lines. Among these isolates, compounds 1-4 exhibited significant cytotoxic activity against CNE2 cell line.

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Keywords

8-hydroxycanthin-6-one
 
canthin-6-one alkaloids
 
CNE2
 
CNE2 cell line
 
compounds 1-4 exhibited significant cytotoxic activity
 
cytotoxic activity
 
new alkaloid
 

Mei-Xiang Jiang