Article

Epstein–Barr virus in autoimmune diseases

and EA 3186 Agents Pathogènes et Inflammation, University of Franche Comté, Besançon, France.
Best practice & research. Clinical rheumatology (Impact Factor: 3.06). 11/2008; 22(5):883-96. DOI: 10.1016/j.berh.2008.09.007
Source: PubMed

ABSTRACT Autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and primary Sjögren's syndrome (pSS) are complex disorders with a genetic background and the involvement of environmental factors, including viruses. The Epstein-Barr virus (EBV) is a plausible candidate for playing a role in the pathophysiology of these diseases. Both SLE and RA are characterized by high titers of anti-EBV antibodies and impaired T-cell responses to EBV antigens. Compared with normal subjects, elevated EBV load in peripheral blood has been observed in SLE and RA. EBV DNA or RNA has been evidenced in target organs of RA (synovium) or pSS (salivary glands). Finally, molecular mimicry has been demonstrated between EBV proteins and self antigens in these three conditions. In addition, SLE, RA, and pSS are associated with an increased risk of lymphoma with a potential role for EBV. The influence of new and emergent treatments of these autoimmune diseases (biological therapies) on EBV load and the course of latent EBV infection requires further studies.

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Available from: Jean Roudier, Aug 21, 2015
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    • "The primary EBV infection occurs asymptomatically in childhood and typically persists throughout the life of the host. EBV is the cause of infectious mononucleosis [7] and is associated with specific forms of cancer, including Hodgkin's lymphoma [8], Burkitt's lymphoma [9], and nasopharyngeal carcinoma [10], and with autoimmune diseases [11]. In most asymptomatic carriers, the virus is periodically replicated, and the infectious virus is known as the EBV lytic cycle, which has been found to be associated with an increasing number of diseases, such as rheumatoid arthritis [12] [13] and infectious mononucleosis [7]. "
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    • "[3] "
    Sjógren,s Syndrome, Edited by Eduardo M. Hernandez, 05/2014: chapter Chapter III: pages 71-96; Nova Science Publisher., ISBN: 978-1-63117-859-7
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    • "Another way in which putrescine levels could become elevated in a cell is from a viral infection, such as an Epstein–Barr virus (EBV) infection. EBV is suspected of having a role in autoimmune diseases (Toussirot and Roudier, 2008). When EBV becomes active in a cell, it increases the activity of the c-Myc protein (Bajaj et al., 2008). "
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