Article

Eosinophilic esophagitis.

University of Pennsylvania School of Medicine, Center for Pediatric Eosinophilic Disorders, Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Gastroenterology Clinics of North America (impact factor: 2.62). 01/2009; 37(4):989-98, xi. DOI:10.1016/j.gtc.2008.09.004 pp.989-98, xi
Source: PubMed

ABSTRACT Eosinophilic esophagitis (EoE) is a disease based on a clinicopathologic diagnosis that involves a localized eosinophilic inflammation of the esophagus. A significant increase in the diagnosis of pediatric EoE has occurred over the past 10 years not only due to a greater recognition of the disease among gastroenterologists, allergists, and pathologists but also secondary to an increased incidence of the disease. EoE is defined by the presence of 15 or more esophageal eosinophils per high-power field isolated to the esophagus associated with clinical symptoms that do not respond to acid suppression therapy. Although the exact mechanism of EoE is unknown, food allergens are thought to have an important role. Effective treatment options include dietary restrictions and various steroid formulations.

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Keywords

acid suppression therapy
 
allergists
 
clinical symptoms
 
clinicopathologic diagnosis
 
Effective treatment options
 
Eosinophilic esophagitis
 
esophageal eosinophils
 
exact mechanism
 
greater recognition
 
increased incidence
 
localized eosinophilic inflammation
 
various steroid formulations
 

Chris A Liacouras