A look inside the diabetic brain: Contributors to diabetes-induced brain aging

Department of Pharmacology, Physiology and Neuroscience University of South Carolina, School of Medicine, Columbia, SC 29208, USA.
Biochimica et Biophysica Acta (Impact Factor: 4.66). 12/2008; 1792(5):444-53. DOI: 10.1016/j.bbadis.2008.10.013
Source: PubMed

ABSTRACT Central nervous system (CNS) complications resulting from diabetes is a problem that is gaining more acceptance and attention. Recent evidence suggests morphological, electrophysiological and cognitive changes, often observed in the hippocampus, in diabetic individuals. Many of the CNS changes observed in diabetic patients and animal models of diabetes are reminiscent of the changes seen in normal aging. The central commonalities between diabetes-induced and age-related CNS changes have led to the theory of advanced brain aging in diabetic patients. This review summarizes the findings of the literature as they relate to the relationship between diabetes and dementia and discusses some of the potential contributors to diabetes-induced CNS impairments.

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Available from: Lawrence P Reagan, Jul 28, 2015
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    • "However, when the ITI is increased, which more directly assesses hippocampal-dependent function, these leptin receptor deficient rats perform more poorly when compared to control rats (Winocur et al., 2005). Interestingly, Zucker rats also exhibit increases in AD-like pathology, including increases in hyper-phosphorylated tau immunoreactivity in the dentate gyrus and CA3 region of the hippocampus (Wrighten et al., 2008). Collectively, these data illustrate that hippocampal synaptic plasticity is impaired in leptin-deficient rodents. "
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