Malassezia furfur fingerprints as possible markers for human phylogeography.
ABSTRACT Malassezia furfur was the first species described within the cosmopolitan yeast genus Malassezia, which now comprises 13 species. Reported isolation rates of these species from healthy and diseased human skin show geographic variations. PCR-fingerprinting with the wild-type phage M13 primer (5'-GAGGGTGGCGGTTCT-3') was applied to investigate phylogeographic associations of M. furfur strains isolated from Scandinavians residing permanently in Greece, in comparison to clinical isolates from Greek, Bulgarian and Chinese native residents. Seven M. furfur strains from Scandinavians were compared with the Neotype strain (CBS1878), CBS global collection strains (n=10) and clinical isolates from Greece (n=4), Bulgaria (n=15) and China (n=6). Scandinavian, Greek and Bulgarian M. furfur strains mostly formed distinct group clusters, providing initial evidence for an association with the host's geographical origin and with the underlying skin condition. These initial data address the hypothesis that M. furfur could be a eukaryotic candidate eligible for phylogeographic studies.
Article: The phylogeography of human viruses.[show abstract] [hide abstract]
ABSTRACT: Viruses, especially those with RNA genomes, represent ideal organisms to study the dynamics of microevolutionary change. In particular, their rapid rate of nucleotide substitution means that the epidemiological processes that shape their diversity act on the same time-scale as mutations are fixed in viral populations. Consequently, the branching structure of virus phylogenies provides a unique insight into spatial and temporal dynamics. Herein, I describe the key processes in virus phylogeography. These are generally associated with the relative rates of dispersal among populations and virus-host codivergence (vicariance), and the division between acute (short-term) and persistent (long-term) infections. These processes will be illustrated by important human viruses - HIV, dengue, rabies, polyomavirus JC and human papillomavirus - which display varying spatial and temporal structures and virus-host relationships. Key research questions for the future will also be established.Molecular Ecology 05/2004; 13(4):745-56. · 6.28 Impact Factor
Article: Update on the genus Malassezia.[show abstract] [hide abstract]
ABSTRACT: Malassezia yeasts are commensals of normal human skin, but also cause pityriasis versicolor, seborrhoeic dermatitis and evidence is accumulating that they play a significant role in atopic eczema/dermatitis syndrome (AEDS; formerly atopic dermatitis). The taxonomy of the genus has changed considerably and is likely to change more in the future. Our understanding of the interaction between Malassezia and the host demonstrates that it has the paradoxical ability to both stimulate and suppress the immune response directed against it and there is a fine balance in its existence at the interface between commensalism and pathogenicity.Medical Mycology 07/2007; 45(4):287-303. · 1.98 Impact Factor
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ABSTRACT: Premature infants in the neonatal intensive care unit (NICU) are at particular risk of invasive fungal infections, and unfortunately, the incidence of fungal septicemia appears to be increasing. Invasive infections caused by species of Candida or Malassezia have been documented in the NICU and are often associated with significant morbidity and mortality. Controversies regarding the diagnosis, treatment, and prevention of such diseases exist. The purpose of this review is to describe the epidemiology, clinical manifestations, diagnostic techniques, treatment, and prevention of invasive infection due to Candida and Malassezia species in the neonatal intensive care setting.Advances in Neonatal Care 05/2006; 6(2):68-77; quiz 78-9.