Burkitt Lymphoma in Brazil Is Characterized by Geographically Distinct Clinicopathologic Features

Pathology Reference Laboratory, Botucatu, São Paulo, Brazil.
American Journal of Clinical Pathology (Impact Factor: 2.51). 01/2009; 130(6):946-56. DOI: 10.1309/AJCP64YOHAWLUMPK
Source: PubMed

ABSTRACT Burkitt lymphoma (BL) is a highly aggressive non-Hodgkin lymphoma with a consistent MYC translocation. Epstein-Barr virus (EBV) has been associated with BL at different frequencies, depending on the clinical variant and geographic regions. This is a large-scale study of BL in Brazil, including 234 patients from 5 geographic regions that are widely disparate socioeconomically, including pediatric (61.1%) and adult (37.6%) populations. EBV was present in 52.6% of all BL cases, varying from 29% (12/42) in the South to 76% (13/17) in the North. Most of the cases were EBV type A. The frequency was higher in the pediatric group, and EBV association within this age range predominated in all regions except the South. Expression of p53 protein was observed in 16.2%, and only rare cases showed p63 expression. BL in Brazil is regionally distinct and has a low incidence of p53 overexpression and a higher-than-expected association with EBV in sporadic cases.

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Available from: Dirk P Dittmer, Sep 28, 2015
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    • "This difference could be explain by the fact that those studies analyzed both adults and pediatric patients together, and that they dot not discriminate between immunocompetent and immunosuppressed individuals. In contrast, variable regionally EBV association with Burkitt's lymphoma was described, varying from 29% in the South to 76% in the North, but higher in pediatric groups from all regions [Queiroga et al., 2008]. "
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    ABSTRACT: The aim of this study is to characterize EBV expression and latency pattern in pediatric Burkitt's lymphoma in a single institution in Argentina. EBV-encoded RNA or protein was analyzed in 27 patients. EBERs was expressed in 37% of patients (29% of immunocompetent and 100% of immunosuppressed patients). EBV-positive cases were observed exclusively in patients younger than 5 years old. EBV association with immunocompetent patients exhibits the sporadic pattern in region under study, while its presence in patients infected with HIV was higher than described previously. EBV latency I profile was present in most of the patients, except for two immunosuppressed patients who displayed LMP1 expression. J. Med. Virol. © 2013 Wiley Periodicals, Inc.
    Journal of Medical Virology 05/2014; 86(5). DOI:10.1002/jmv.23737 · 2.35 Impact Factor
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    • "BL in Brazil is considered of an intermediate type, clinically resembling sporadic BL, mostly presenting abdominal involvement and rarely affecting the jaws, with about 60% of the cases revealing positivity for EBV (16,17). In one of the largest studies of BL conducted in Brazil, 234 cases from all geographic regions of the country were analyzed, showing that in only 5 cases the jaws were affected (8). Similarly, in the 37 BL cases described by Klumb et al. (11) no case showed gnathic involvement, whereas the abdominal region was affected in 81% of the individuals. "
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    ABSTRACT: Objectives: To describe the clinicopathologic and immunohistochemical features of Burkitt’s lymphoma of the jaws in 7 patients of Northern Brazil. Study Design: Clinical data concerning gender, age, affected site, clinical presentation, symptomatology and follow-up were collected from the clinical files. Histopathology was complemented with a broad immunohistochemical panel and in situ hybridization for Epstein-Barr virus (EBV). Results: Most of the patients were infants and 5 out of 7 were males. The mandible was affected in 5 cases and all patients also presented abdominal involvement. All cases were positive for CD45, CD20, CD79a, CD10, Bcl-6 and EBV. Ki-67 proliferative index was approximately 100%. Six patients were treated with R-CHOP (Rituximab + Cyclophosphamide, Doxorubicin, Vincristine and Prednisolone) chemotherapy, and 2 of these died of the disease. One young adult patient refused treatment and died 3 months after initial diagnosis. Conclusions: Burkitt’s lymphoma of the jaws diagnosed in the Amazon region of Brazil present similar clinicopathologic features to those described in endemic areas of Africa, including EBV positivity. Key words:Burkitt’s lymphoma, EBV, Brazil, Amazon region.
    Medicina oral, patologia oral y cirugia bucal 08/2013; 19(1). DOI:10.4317/medoral.18936 · 1.17 Impact Factor
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    • "Whereas eBL is linked to EBV and malaria, this factor appears to be less important in sBL where EBV DNA is integrated or clonally detected in only 20–30% of tumors [27] [28]. Previous studies on BL in Brazil demonstrated intermediate features between endemic and sporadic cases regarding EBV–tumor association and clinical disease presentation [29] [30] [31] [32]. However, the incidence rates of BL in different regions of Brazil have been unknown until now. "
    Dataset: CANEP422
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