Reduced serotonergic functioning changes heart rate in ADHD.
ABSTRACT Reduced mean heart rate (HR) was shown to be a biophysiological marker for aggression, which in turn was proven to be related to changed serotonergic neurotransmission. A total of 16 ADHD-diagnosed boys were subjected to rapid tryptophan depletion (RTD) and a placebo in a double-blind within-subject crossover-design. Mean HR was assessed under RTD/placebo. Low impulsive patients behaving aggressively under RTD showed a lowered HR under RTD versus placebo. Diminished 5-HT functioning was associated with lowered HR and aggressive behaviour.
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ABSTRACT: Video podcast available Go to www.actapsychiatrica.com to watch an accompanying commentary by Guest Editor Florian Daniel Zepf.Acta Psychiatrica Scandinavica 08/2013; 128(2):105-6. · 4.86 Impact Factor
Dataset: Biskup et al. 2012 PLoS ONE
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ABSTRACT: We investigated the impact of acute tryptophan depletion (ATD) and reduced brain serotonin synthesis on physiological arousal in 15 young people with ADHD participating in an aggression-inducing game. ATD was not associated with altered physiological arousal, as indexed by electrodermal activity (EDA). Baseline aggression was negatively correlated with the mean ATD effect on EDA. In accordance with the low arousal theory related to aggressive behavior, subjects with reduced physiological responsiveness/lower electrodermal reactivity to ATD tended to display elevated externalizing behavior.Journal of Neural Transmission 12/2013; 121(4). · 2.87 Impact Factor