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    ABSTRACT: Background. Fine-needle aspiration (FNA) can cause misdiagnosis of cytomorphological findings between parathyroid and thyroid lesions. Case Presentation. A 31-year-old man presented with a palpable neck mass on the right thyroid lobe. FNA cytology was reported as intrathyroidal lymphoid hyperplasia. After 5 years, repeated FNA was done on the enlarged nodule with result of Hürthle cell lesion. Prior to right lobectomy, laboratories revealed elevated serum calcium and parathyroid hormone (PTH). Careful history taking revealed chronic knee pain and ossifying fibroma at the maxilla. Ultrasonography showed a 2.8 cm mass inferior to right thyroid lobe. Pathology from en bloc resection was parathyroid carcinoma and immunohistochemical study revealed positivity for PTH. Genetic analysis found somatic mutation of CDC73 gene in exon1 (c.70delG) which caused premature stop codon in amino acid 26 (p.Glu24Lysfs*2). The final diagnosis was hyperparathyroidism-jaw tumor syndrome. Conclusions. FNA cytology of parathyroid can mimic thyroid lesion. It is important to consider and correlate the entire information from clinical history, laboratory, imaging, and FNA.
    01/2014; 2014:680876. DOI:10.1155/2014/680876
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    ABSTRACT: Objective: Primary hyperparathyroidism (PHPT) is one of the most frequently diagnosed endocrine disorders, but few studies focused on hospital management of the disease in Europe. We investigated the frequency of hospital admission for diagnosis and surgical treatment for PHPT in Italy. Design: retrospective study. Methods: We retrieved data from the "Record of Hospital Discharge" (SDO) of the Italian Health Ministry, from the year 2006 to 2011 and analyzed the codes corresponding to PHPT-related diagnoses and surgical procedures. Results: Overall, 46,275 hospitalization episodes for PHPT were identified during the entire period [69% in women and 31% in men); mean age 63.3±39.8 years]. Patients' mean age significantly increased during the years (p<0.001). The mean length of stay was 8.2±10.5 days (28% of the episodes requiring less than 3 days of stay). Admissions for surgical procedures were 12,457 accounting for 26.9% of the total hospitalizations. There was a trend to a significant increase in the percentage of surgery (p<0.05). The mean hospitalization rate for PHPT was 12.9/100,000 inhabitants/year and the trend showed a significant decrease during the period 2006-2011 (p<0.0001). The mean hospitalization rate for PHPT surgery was 3.65/100,000 per year, significantly increasing over time (p<0.001). Conclusions: PHPT considerably influences the Italian Hospital healthcare system. We observed a tendency to a decrease in the frequency of hospitalization during the period 2006-2011, most probably because of economic issues, a concomitant increased age of patients, and, interestingly, also a progressive increase in the percentage of surgical treatment among patients admitted for PHPT.
    European Journal of Endocrinology 07/2014; 171(4). DOI:10.1530/EJE-14-0493 · 3.69 Impact Factor
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    ABSTRACT: Rare endocrine-metabolic diseases (REMD) represent an important area in the field of medicine and pharmacology. The rare diseases of interest to endocrinologists involve all fields of endocrinology, including rare diseases of the pituitary, thyroid and adrenal glands, paraganglia, ovary and testis, disorders of bone and mineral metabolism, energy and lipid metabolism, water metabolism, and syndromes with possible involvement of multiple endocrine glands, and neuroendocrine tumors. Taking advantage of the constitution of a study group on REMD within the Italian Society of Endocrinology, consisting of basic and clinical scientists, a document on the taxonomy of REMD has been produced.
    Journal of endocrinological investigation 11/2014; 38(2). DOI:10.1007/s40618-014-0202-6 · 1.65 Impact Factor

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