Article

Parathyroid Carcinoma

Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy.
Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research (Impact Factor: 6.59). 01/2009; 23(12):1869-80. DOI: 10.1359/jbmr.081018
Source: PubMed

ABSTRACT The best opportunity to cure parathyroid carcinoma is to diagnose it before or at the time of parathyroid surgery and for the tumor to be completely removed at the time of the initial operation. Because the diagnosis is often not clear at the time of presentation, recent attempts to distinguish between benign and malignant disease both by genetic and immunohistological analyses are promising. The disease is indolent but progressive. Attempts to remove local recurrences and distant metastases can provide short- and long-term control. Other therapeutic approaches with chemotherapy and radiotherapy are not helpful. Available medical therapy targets the consequence of the disease (hypercalcemia) rather than the disease itself.

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Available from: Shonni J Silverberg, Jun 03, 2015
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