Determination of renal vascular resistance in dogs with diabetes mellitus and hyperadrenocorticism

Animal Medicine and Surgery Department, Universitat Autónoma de Barcelona, Veterinary Teaching Hospital, Edifici V Campus, 08913 Cerdanyola del Vallès, Barcelona, Spain.
The Veterinary record (Impact Factor: 1.49). 12/2008; 163(20):592-6. DOI: 10.1136/vr.163.20.592
Source: PubMed


In dogs, diabetes mellitus and hyperadrenocorticism are causes of hypertension associated with increases in vascular peripheral resistance. In human patients, the renal resistive index (ri) and pulsatility index (pi) are related to hypertension and diabetes and are used as indicators of disease severity. In this study the renal vascular resistance was measured in 12 dogs with hyperadrenocorticism, three with diabetes mellitus and four with both conditions, and the possible relationships between the two indices, blood pressure and biochemical parameters were investigated. Hypertension, defined as a systolic blood pressure more than 150 mmHg, was recorded in two of the dogs with hyperadrenocorticism and three of the dogs with hyperadrenocorticism and diabetes. The overall mean values for ri, pi and systolic blood pressure were higher in the diseased group of dogs than in 27 healthy dogs, and both indices were correlated with blood glucose concentration.

8 Reads
  • Source
    • "The incidence of hypertension in dogs affected with HAC has been reported to range from 52.6 (n = 10/16) to 86.1% (n = 31/36) [3,4]. In this study, the incidence of hypertension in dogs with HAC was 46.7%, which was significantly higher than the 12% incidence observed in clinically healthy dogs, supporting previous observations that dogs affected by HAC tend to have hypertension [3,4]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Hypertension and proteinuria are medical complications associated with the multisystemic effects of long-term hypercortisolism in dogs with hyperadrenocorticism (HAC). This study investigated the relationships among adrenocorticotropic hormone (ACTH)-stimulation test results, systemic blood pressure, and microalbuminuria in clinically-healthy dogs (n = 100), in dogs affected with naturally occurring pituitary-dependent (PDH; n = 40), or adrenal-dependent hyperadrenocorticism (ADH; n = 30). Mean systemic blood pressure was similar between clinically healthy dogs and dogs with HAC (p = 0.803). However the incidence of hypertension was highest in dogs with ADH (p = 0.017), followed by dogs with PDH, with the lowest levels in clinically healthy dogs (p = 0.019). Presence of microalbuminuria and albuminuria in clinically healthy dogs and dogs affected with HAC was significantly different (p < 0.001); incidences of albuminuria followed the same pattern of hypertension; highest incidence in dogs with ADH, and lowest level in clinically healthy dogs; but microalbuminuria showed a different pattern: clinically healthy dogs had highest incidences and dogs with ADH had lowest incidence. The presence of albuminuria was not associated with blood pressure values, regardless of whether dogs were clinically healthy or affected with ADH or PDH (p = 0.306). Higher incidence of hypertension and albuminuria, not microalbuminuria was seen in dogs affected with HAC compared to clinically healthy dogs; incidence of hypertension and albuminuria was significantly higher in dogs affected with ADH compared to PDH. However, presence of albuminuria was not correlated with systemic blood pressure.
    Acta Veterinaria Scandinavica 11/2010; 52(1):61. DOI:10.1186/1751-0147-52-61 · 1.38 Impact Factor
  • Source

  • [Show abstract] [Hide abstract]
    ABSTRACT: Hypertension is classified as idiopathic or secondary. In animals with idiopathic hypertension, persistently elevated blood pressure is not caused by an identifiable underlying or predisposing disease. Until recently, more than 95% of cases of hypertension in humans were diagnosed as idiopathic. New studies have shown, however, a much higher prevalence of secondary causes, such as primary hyperaldosteronism. In dogs and cats, secondary hypertension is the most prevalent form and is subclassified into renal and endocrine hypertension. This review focuses on the most common causes of endocrine hypertension in dogs and cats.
    Veterinary Clinics of North America Small Animal Practice 03/2010; 40(2):335-52. DOI:10.1016/j.cvsm.2009.10.005 · 0.82 Impact Factor
Show more