Molecular biology of head and neck cancer: risks and pathways.

Department of Otolaryngology-Head & Neck Surgery, University of North Carolina at Chapel Hill, CB #7070, Chapel Hill, NC 27599, USA.
Hematology/Oncology Clinics of North America (Impact Factor: 2.07). 01/2009; 22(6):1099-124, vii. DOI: 10.1016/j.hoc.2008.08.007
Source: PubMed

ABSTRACT Patients present with a differential baseline risk of cancer based on normal and expected variations in genes associated with cancer. The baseline risk of developing cancer is acted on throughout life as the genome of different cells interacts with the environment in the form of exposures (eg, toxins, infections). As genetic damage is incurred throughout a lifetime (directly to DNA sequences or to the epigenome), events are set in motion to progressively disrupt normal cellular pathways toward tumorigenesis. This article attempts to characterize broad categories of genetic aberrations and pathways in a manner that might be useful for the clinician to understand the risk of developing cancer, the pathways that are disrupted, and the potential for molecular-based diagnostics.

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Available from: Michael Stadler, Dec 19, 2014
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    • "Head and neck cancer include tumours of the upper aerodigestive tract, parapharyngeal space, paranasal sinuses, thyroid gland, parathyroid gland as well as major and minor salivary glands. Besides these, tumours of the bone and skin present in the head and neck region are also included in head and neck cancer (Stadler et al., 2006). Head and neck cancer (HNNC) is the fifth most common cancer affecting across the globe (Marcu and Yeoh, 2009). "
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