Article

A microRNA encoded in a highly conserved part of the mammalian HMGA2 gene.

Small Animal Clinic, University of Veterinary Medicine and Research Cluster of Excellence REBIRTH, Bischofsholer Damm 15, D-30173 Hannover, Germany.
Cancer genetics and cytogenetics (impact factor: 1.54). 12/2008; 187(1):43-4. DOI:10.1016/j.cancergencyto.2008.07.009 pp.43-4
Source: PubMed

ABSTRACT The high mobility group protein HMGA2 plays an important role as a chromatin component of stem cells and as a protein causally related to the development of a variety of benign tumors (e.g., uterine leiomyomas, lipomas, and pleomorphic adenomas of the salivary glands). Herein, the existence of a highly conserved region within intron 3 of HMGA2 encoding a microRNA is described. The co-expression with HMGA2 suggests that as an intronic microRNA, this microRNA may cooperate with HMGA2 in its physiological and/or aberrant functions.

0 0
 · 
0 Bookmarks
 · 
35 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

aberrant functions
 
chromatin component
 
conserved region
 
Herein
 
HMGA2
 
HMGA2 encoding
 
mobility group protein HMGA2
 
pleomorphic adenomas
 
salivary glands
 
uterine leiomyomas
 

Inga von Ahsen